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Rank: Junction Consistence: Hi-C Sense-ANTIsense

Mass-spec hits Read-through chimeras Breakpoints RNAseq evidence
UniProtKB hits
Organisms
Homo Sapiens Mus musculus D.Melanogaster
Rattus Norvegicus Bos Taurus Danio Rerio
Saccharomyces Cerevisiae Sus ScrofaAll organisms

Result for the search of Gene Name/NCBI ID(s): 'WHSC1'

Total of fusion sequences: 20 (from 10,657,267 parsed EST/mRNAs. Last update: 2020-11-05 10:39:19)

Organism Fusion:
Graphical View,
Annotation,
PPI network 		Head Gene (1) Tail Gene (2) Rank,
Deviation:
Eloc(x)
Sloc(y) 		Fusion type RNA Hi-C,
RNAseq,
Mass-spec
evidences		 Cancer
Breakpoint,
PubMed(s)
Name(s)1,
transcript		 Start1..End1
Ident1% 		Strand1
Chrom1 		Name(s)2,
transcript		 Start2..End2
Ident2% 		Strand2
Chrom2
1234,5,67,1989,10,1112,2513,14,15321617
1
Homo Sapiens		 ChimerDB

ANNOTATION OF CHIMERA FUSION

GenBank ID: CA431231 FASTA
Head Gene (1) Alignment: NSD2 | OMIM: 602952 Tail Gene (2) Alignment: RBMS1 | OMIM: 602310 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
74684-1934846193486580oncogene,
protein-coding		59372+160272151160272760151protein-coding 771 hg38
Updated: 2019-02-21
Owner: ChiTaRS
NM_133330.2		1..20
100.0%		-
4
XM_005246739.2		18..628
99.4%		+
2		1
0
0		intron-exon
2
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: U73660 FASTA
Head Gene (1) Alignment: IGH | OMIM: 16777215 Tail Gene (2) Alignment: NSD2 | OMIM: 602952 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
349214+10562732510562745800oncogene,
protein-coding		74684-1903442190361800oncogene,
protein-coding		 313 hg38
Updated: 2019-09-04
Owner: ChiTaRS
IGH
1..134
98.6%		+
14
NM_133330.2		135..311
100.0%		-
4		0
31364
65535		intron-intronBREAKPOINTs
3
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: U73661 FASTA
Head Gene (1) Alignment: NSD2 | OMIM: 602952 Tail Gene (2) Alignment: IGH | OMIM: 16777215 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
74684-1872166187225400oncogene,
protein-coding		349214+10585909010585915600oncogene,
protein-coding		 152 hg38
Updated: 2019-09-04
Owner: ChiTaRS
NM_133330.2		1..88
100.0%		-
4
IGH
87..152
100.0%		+
14		0
31364
65535		intron-intronBREAKPOINTs
4
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: BC094825 FASTA
UniProtKB: O96028 Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.43) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)
Fusion Gene(s): NSD2 KIAA1090 MMSET TRX5 WHSC1
Head Gene (1) Alignment: NSD2 | OMIM: 602952 Tail Gene (2) Alignment: KPNA6 | OMIM: 610563 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
74684+19551591979796101oncogene,
protein-coding		236331+321551093215512900protein-coding 2670 hg38
Updated: 2019-03-03
Owner: ChiTaRS
NM_133330.2		4..2652
100.0%		+
4
XM_024446165.1		2650..2670
100.0%		+
1		1
0
0		exon-intron
5
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: BC012026 FASTA
UniProtKB: Q96EQ7 HCG2010942
Fusion Gene(s): hCG_2010942
Head Gene (1) Alignment: SMTN | OMIM: 602127 Tail Gene (2) Alignment: NSD2 | OMIM: 602952 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
652522-310821563108356520protein-coding74684-1875281187530200oncogene,
protein-coding		 1433 hg38
Updated: 2019-04-13
Owner: ChiTaRS
XM_011530333.3		1..1410
100.0%		-
22
NM_133330.2		1409..1430
100.0%		-
4		1
0
0		intron-intron
6
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: AW390894 FASTA
Head Gene (1) Alignment: GSTP1 | OMIM: 134660 Tail Gene (2) Alignment: NSD2 | OMIM: 602952 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
295011-675852116758640771tumor suppressor,
protein-coding		74684+1961033197488451oncogene,
protein-coding		 306 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
GST_N (PF02798, IPR004045) 76 4 75 7.1e-10 25.500 Glutathione S-transferase, N-terminal domain
GST_C_3 (PF14497, IPR004046) 99 98 156 7.3e-10 25.300 Glutathione S-transferase, C-terminal domain
SET (PF00856, IPR001214, SM00317) 169 200 298 7.4e-20 58.200 SET domain
zf-HC5HC2H (PF13771) 90 326 425 7.3e-05 9.300 PHD-like zinc-binding domain
Updated: 2019-02-21
Owner: ChiTaRS
NM_000852.3		19..175
98.1%		-
11
NM_133330.2		164..304
100.0%		+
4		0
13732
0		exon-exon
7
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: AW390893 FASTA
Head Gene (1) Alignment: GSTP1 | OMIM: 134660 Tail Gene (2) Alignment: NSD2 | OMIM: 602952 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
295011-675852116758617461tumor suppressor,
protein-coding		74684+1961033196115251oncogene,
protein-coding		 233 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
RCDG1 (PF15725, IPR031457) 83 40 87 0.0012 5.600 Renal cancer differentiation gene 1 protein
SET (PF00856, IPR001214, SM00317) 169 148 259 6.8e-20 58.300 SET domain
zf-HC5HC2H (PF13771) 90 287 386 6.2e-05 9.500 PHD-like zinc-binding domain
Updated: 2019-02-21
Owner: ChiTaRS
NM_000852.3		1..98
99.0%		-
11
NM_133330.2		87..206
98.4%		+
4		0
13732
0		exon-exon
8
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: AW772569 FASTA
Head Gene (1) Alignment: NSD2 | OMIM: 602952 Tail Gene (2) Alignment: RPS15A | OMIM: 603674 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
74684+1898692189871100oncogene,
protein-coding		621016+187829681878910441protein-coding 450 hg38
Updated: 2019-11-28
Owner: ChiTaRS
NM_133330.2		9..28
100.0%		+
4
NM_001030009.1		24..450
98.9%		+
16		1
0
0		intron-exon
9
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: AV682250 FASTA
Head Gene (1) Alignment: NSD2 | OMIM: 602952 Tail Gene (2) Alignment: LOC729254 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
74684+19795621979796241oncogene,
protein-coding		7292542-19181610919181613810protein-coding,
ncRNA		 655 hg38
Updated: 2019-01-31
Owner: ChiTaRS
NM_133330.2		1..235
100.0%		+
4		 LOC729254
XM_017005453.2		233..262
100.0%		-
2		1
0
0		exon-intron
10
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: BE079790 FASTA
Head Gene (1) Alignment: NSD2 | OMIM: 602952 Tail Gene (2) Alignment: NSD2 | OMIM: 602952 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
74684-1918213191849471oncogene,
protein-coding		74684+19010891955244211oncogene,
protein-coding		 560 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
PWWP (PF00855, IPR000313, SM00293) 96 633 747 2.2e-25 75.300 PWWP domain
HMG_box (PF00505, IPR009071, SM00398) 69 868 921 1.9e-13 37.000 HMG (high mobility group) box
zf-HC5HC2H (PF13771) 90 1052 1114 4.4e-06 13.200 PHD-like zinc-binding domain
PHD (PF00628, IPR019787, SM00249) 52 1082 1126 5e-09 22.300 PHD-finger
zf-RING_2 (PF13639, IPR001841, SM00184) 44 1128 1181 0.00011 8.700 Ring finger domain
SET (PF00856, IPR001214, SM00317) 169 1487 1593 1.3e-25 76.900 SET domain
zf-HC5HC2H_2 (PF13832) 110 1623 1688 1.9e-06 14.300 PHD-zinc-finger like domain
Updated: 2019-02-20
Owner: ChiTaRS
NM_133330.2		55..337
95.4%		-
4
NM_133330.2		328..560
98.8%		+
4		1
0
0		exon-exon

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