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Rank: Junction Consistence: Hi-C Sense-ANTIsense

Mass-spec hits Read-through chimeras Breakpoints RNAseq evidence
UniProtKB hits
Organisms
Homo Sapiens Mus musculus D.Melanogaster
Rattus Norvegicus Bos Taurus Danio Rerio
Saccharomyces Cerevisiae Sus ScrofaAll organisms

Result for the search of Gene Name/NCBI ID(s): 'NRSN2'

Total of fusion sequences: 4 (from 1,393,046 parsed EST/mRNAs. Last update 2019-09-04)

Organism Fusion:
Graphical View,
Annotation,
PPI network 		Head Gene (1) Tail Gene (2) Rank,
Deviation:
Eloc(x)
Sloc(y) 		Fusion type RNA Hi-C,
RNAseq,
Mass-spec
evidences		 Cancer
Breakpoint,
PubMed(s)
Name(s)1,
transcript		 Start1..End1
Ident1% 		Strand1
Chrom1 		Name(s)2,
transcript		 Start2..End2
Ident2% 		Strand2
Chrom2
1234,5,67,1989,10,1112,2513,14,15321617
1
Homo Sapiens		SplGraphs

ANNOTATION OF CHIMERA FUSION

GenBank ID: AB040942 FASTA
UniProtKB: Q9P219 Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2)
Fusion Gene(s): CCDC88C DAPLE KIAA1509
Head Gene (1) Alignment: NRSN2 | OMIM: 610666 Tail Gene (2) Alignment: CCDC88C | OMIM: 611204 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
8002320+35360735374461tumor suppressor44019314-9127132591313694301protein-coding 5400 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
Neurensin (PF14927) 134 22 155 7.2e-47 144.700 Neurensin
HOOK (PF05622, IPR008636) 702 2000 2565 1.8e-38 118.200 HOOK protein
GAS (PF13851, IPR025593) 200 2540 2636 3.1e-05 9.600 Growth-arrest specific micro-tubule binding
KASH_CCD (PF14662, IPR028168) 191 2596 2724 2.8e-05 10.200 Coiled-coil region of CCDC155 or KASH
DUF4472 (PF14739, IPR029329) 107 2812 2896 8.3e-06 12.800 Domain of unknown function (DUF4472)
DMPK_coil (PF08826, IPR014930) 61 2885 2909 0.035 0.600 DMPK coiled coil domain like
Rootletin (PF15035) 186 2937 3003 0.00012 8.400 Ciliary rootlet component, centrosome cohesion
DUF724 (PF05266, IPR007930) 188 3014 3111 0.00013 8.000 Protein of unknown function (DUF724)
HALZ (PF02183, IPR003106, SM00340) 43 3096 3133 0.00033 7.200 Homeobox associated leucine zipper
Fez1 (PF06818) 198 3161 3308 1.2e-05 12.000 Fez1
Mod_r (PF07200, IPR009851) 146 3280 3372 2.4e-05 10.700 Modifier of rudimentary (Mod(r)) protein
Updated: 2019-02-20
Owner: ChiTaRS
NM_001323679.1		2..138
100.0%		+
20
XM_011536796.2		135..5400
99.9%		-
14		1
0
0		exon-exon
2
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: EC563344 FASTA
Head Gene (1) Alignment: NRSN2 | OMIM: 610666 Tail Gene (2) Alignment: AC025187.1 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
8002320+35377535387411tumor suppressor5-4039831403986100 113 hg38
Updated: 2019-03-25
Owner: ChiTaRS
NM_001323679.1		2..100
100.0%		+
20		 AC025187.1 80..109
96.6%		-
5		1
0
0		exon-intron
3
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: EC577524 FASTA
Head Gene (1) Alignment: NRSN2 | OMIM: 610666 Tail Gene (2) Alignment: AC025187.1 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
8002320+35377535387411tumor suppressor5-4039831403986100 113 hg38
Updated: 2019-03-25
Owner: ChiTaRS
NM_001323679.1		1..100
100.0%		+
20		 AC025187.1 80..109
96.6%		-
5		1
0
0		exon-intron
4
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: AI199579 FASTA
Head Gene (1) Alignment: HNRNPUL2-BSCL2 Tail Gene (2) Alignment: NRSN2 | OMIM: 610666 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
10053459511+6271475062714811110ncRNA8002320-35321235360921tumor suppressor 458 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
SAP (PF02037, IPR003034, SM00513) 35 67 101 3.9e-12 32.000 SAP domain
Ribosomal_60s (PF00428, IPR001813) 88 91 164 0.0088 2.900 60s Acidic ribosomal protein
CENP-B_dimeris (PF09026, IPR015115) 100 130 172 0.0028 4.400 Centromere protein B dimerisation domain
SPRY (PF00622, IPR003877, SM00449) 120 355 481 1.6e-19 56.400 SPRY domain
AAA_33 (PF13671) 143 518 663 1.1e-27 83.200 AAA domain
Updated: 2019-02-20
Owner: ChiTaRS
HNRNPUL2-BSCL2
H3BQZ7
NR_037946.1		1..62
100.0%		+
11
NM_001323679.1		60..455
99.5%		-
20		1
0
0		intron-exon

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