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Rank: Junction Consistence: Hi-C Sense-ANTIsense

Mass-spec hits Read-through chimeras Breakpoints RNAseq evidence
UniProtKB hits
Organisms
Homo Sapiens Mus musculus D.Melanogaster
Rattus Norvegicus Bos Taurus Danio Rerio
Saccharomyces Cerevisiae Sus ScrofaAll organisms

Result for the search of Gene Name/NCBI ID(s): 'NF2'

Total of fusion sequences: 14 (from 1493742 parsed EST/mRNAs. Last update 2019-12-05 16:32:10)

Organism Fusion:
Graphical View,
Annotation,
PPI network 		Head Gene (1) Tail Gene (2) Rank,
Deviation:
Eloc(x)
Sloc(y) 		Fusion type RNA Hi-C,
RNAseq,
Mass-spec
evidences		 Cancer
Breakpoint,
PubMed(s)
Name(s)1,
transcript		 Start1..End1
Ident1% 		Strand1
Chrom1 		Name(s)2,
transcript		 Start2..End2
Ident2% 		Strand2
Chrom2
1234,5,67,1989,10,1112,2513,14,15321617
1
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: BF687576 FASTA
Head Gene (1) Alignment: NF2 | OMIM: 607379 Tail Gene (2) Alignment: MTMR3 | OMIM: 603558 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
477122+296494202964958540oncogene,
tumor suppressor		889722+2998221729982243170oncogene 505 hg38
Updated: 2019-01-09
Owner: ChiTaRS
NM_181832.2		1..153
95.6%		+
22
XM_005261803.2		154..180
95.6%		+
22		1
0
0		intron-intron

Hi-C contacts of chimeric junction

Fusion Gene1 chromosome1 junction start1 junction end1 Hi-C point1 Δ1 Gene2 chromosome2 junction start2 junction end2 Hi-C point2 Δ2 Cell lines (Cellosaurus ID)
2319--32-825--33-34
BF687576 NF2 22 29649584 29649585 29644011 5573 MTMR3 22 29982217 29982218 29984011 1793 GM12878 (CVCL_7526)
BF687576 NF2 22 29649584 29649585 29654011 4426 MTMR3 22 29982217 29982218 29984011 1793 GM12878 (CVCL_7526)
2
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: NM_181831 FASTA
UniProtKB: A0A024R1D9 Neurofibromin 2 (Bilateral acoustic neuroma), isoform CRA_d
Fusion Gene(s): NF2 hCG_2011004
UniProtKB: P35240 Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin)
Fusion Gene(s): NF2 SCH
Head Gene (1) Alignment: NF2 | OMIM: 607379 Tail Gene (2) Alignment: CPNE3 | OMIM: 604207 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
477122+2960355629683915161oncogene,
tumor suppressor		88958-865225518652263400protein-coding 2217 hg38
Updated: 2019-06-05
Owner: ChiTaRS
NM_181825.2		1..2191
100.0%		+
22
XM_017013945.2		2136..2217
97.5%		-
8		1
0
0		exon-intron
3
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: BC003112 FASTA
UniProtKB: P35240 Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin)
Fusion Gene(s): NF2 SCH
Head Gene (1) Alignment: NF2 | OMIM: 607379 Tail Gene (2) Alignment: CPNE3 | OMIM: 604207 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
477122+2960372729683915161oncogene,
tumor suppressor		88958-865225518652263400protein-coding 2046 hg38
Updated: 2019-06-05
Owner: ChiTaRS
NM_181825.2		1..2020
100.0%		+
22
XM_017013945.2		1965..2046
97.5%		-
8		1
0
0		exon-intron
4
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: BF339912 FASTA
Head Gene (1) Alignment: TWF2 | OMIM: 607433 Tail Gene (2) Alignment: NF2 | OMIM: 607379 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
113443-522286105222901311protein-coding477122+2961674129616763170oncogene,
tumor suppressor		 421 hg38
Updated: 2019-01-02
Owner: ChiTaRS
NM_007284.3		2..404
100.0%		-
3
XM_017028810.1		399..421
100.0%		+
22		1
0
0		exon-intron
5
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: BF666966 FASTA
Head Gene (1) Alignment: NF2 | OMIM: 607379 Tail Gene (2) Alignment: NF2 | OMIM: 607379 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
477122+2969562729695784171oncogene,
tumor suppressor		477122-296962222969675311oncogene,
tumor suppressor		 851 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
FERM_N (PF09379, IPR018979) 65 173 234 6.7e-15 41.200 FERM N-terminal domain
FERM_M (PF00373, IPR019748) 118 252 369 1.4e-30 92.400 FERM central domain
FERM_C (PF09380, IPR018980) 94 373 462 1e-27 82.700 FERM C-terminal PH-like domain
ERM (PF00769, IPR011259) 243 494 742 1.7e-75 240.100 Ezrin/radixin/moesin family
Updated: 2019-01-29
Owner: ChiTaRS
NM_181832.2		1..158
99.4%		+
22
NM_181832.2		149..675
98.7%		-
22		1
0
0		exon-exon
6
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: EC532261 FASTA
Head Gene (1) Alignment: NF2 | OMIM: 607379 Tail Gene (2) Alignment: FOLH1 | OMIM: 600934 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
477122+296117782961209700oncogene,
tumor suppressor		234611+491811294918121300protein-coding 92 hg38
Updated: 2019-04-05
Owner: ChiTaRS
NM_016418.5		1..76
96.0%		+
22
XM_017017434.1		8..91
96.4%		+
11		1
0
0		intron-intron
7
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: AA420653 FASTA
Head Gene (1) Alignment: TGM4 | OMIM: 600585 Tail Gene (2) Alignment: NF2 | OMIM: 607379 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
70473+449142414491460111protein-coding477122+296167412961676100oncogene,
tumor suppressor		 388 hg38
Updated: 2019-04-13
Owner: ChiTaRS
XM_011534042.2		9..369
97.6%		+
3
NM_016418.5		361..381
100.0%		+
22		1
0
0		exon-intron
8
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: AI824686 FASTA
Head Gene (1) Alignment: CDKL3 | OMIM: 608459 Tail Gene (2) Alignment: NF2 | OMIM: 607379 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
512655-134285845134354949110protein-coding477122+296508482965101500oncogene,
tumor suppressor		 193 hg38
Updated: 2019-04-13
Owner: ChiTaRS
XM_024446087.1		1..113
95.5%		-
5
NM_016418.5		62..145
96.6%		+
22		1
0
0		intron-intron
9
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: AI082468 FASTA
Head Gene (1) Alignment: NF2 | OMIM: 607379 Tail Gene (2) Alignment: IGL Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
477122-296491362964954440oncogene,
tumor suppressor		353522+225477012254818600oncogene 501 hg38
Updated: 2019-02-17
Owner: ChiTaRS
NM_181832.2		1..25
100.0%		-
22		 15..501
99.4%		+
22		1
0
0		intron-intron
10
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: BC071653 FASTA
Head Gene (1) Alignment: FBXO10 | OMIM: 609092 Tail Gene (2) Alignment: NF2 | OMIM: 607379 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
262679-375357173753617890protein-coding477122+296978222969860011oncogene,
tumor suppressor		 1253 hg38
Updated: 2019-02-20
Owner: ChiTaRS
XM_006716754.4		1..462
99.8%		-
9
NM_181832.2		458..1236
100.0%		+
22		1
0
0		intron-exon

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