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Rank: Junction Consistence: Hi-C Sense-ANTIsense

Mass-spec hits Read-through chimeras Breakpoints RNAseq evidence
UniProtKB hits
Organisms
Homo Sapiens Mus musculus D.Melanogaster
Rattus Norvegicus Bos Taurus Danio Rerio
Saccharomyces Cerevisiae Sus ScrofaAll organisms

Result for the search of Gene Name/NCBI ID(s): 'HSPB1'

Total of fusion sequences: 45 (from 1493742 parsed EST/mRNAs. Last update 2019-12-11 12:04:16)

Organism Fusion:
Graphical View,
Annotation,
PPI network 		Head Gene (1) Tail Gene (2) Rank,
Deviation:
Eloc(x)
Sloc(y) 		Fusion type RNA Hi-C,
RNAseq,
Mass-spec
evidences		 Cancer
Breakpoint,
PubMed(s)
Name(s)1,
transcript		 Start1..End1
Ident1% 		Strand1
Chrom1 		Name(s)2,
transcript		 Start2..End2
Ident2% 		Strand2
Chrom2
1234,5,67,1989,10,1112,2513,14,15321617
1
Homo Sapiens		SplGraphs

ANNOTATION OF CHIMERA FUSION

GenBank ID: DA893722 FASTA
Head Gene (1) Alignment: TNNC2 | OMIM: 191039 Tail Gene (2) Alignment: HSPB1 | OMIM: 602195 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
712520-458245854582731261protein-coding33157+763029257630407131oncogene 475 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
EF-hand_6 (PF13405, IPR002048) 31 40 59 4.8e-06 12.800 EF-hand domain
HSP20 (PF00011, IPR002068) 101 73 170 3.6e-28 84.000 Hsp20/alpha crystallin family
Updated: 2019-02-02
Owner: ChiTaRS
NM_003279.2		1..173
100.0%		-
20
NM_001540.4		172..475
99.7%		+
7		1
0
0		exon-exonSpes-1
2
Homo Sapiens		SplGraphs

ANNOTATION OF CHIMERA FUSION

GenBank ID: DA283619 FASTA
Head Gene (1) Alignment: HSPB1 | OMIM: 602195 Tail Gene (2) Alignment: RAPGEF5 | OMIM: 609527 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
33157+763026757630278711oncogene97717-2211988222120345261protein-coding 575 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
PA14 (PF07691, IPR011658, SM00758) 146 262 321 9.9e-08 18.100 PA14 domain
Updated: 2019-02-21
Owner: ChiTaRS
NM_001540.4		1..113
100.0%		+
7
XM_005249916.1		112..575
100.0%		-
7		1
0
0		exon-exon
3
Homo Sapiens		SplGraphs

ANNOTATION OF CHIMERA FUSION

GenBank ID: AJ710478 FASTA
Head Gene (1) Alignment: SKP1 | OMIM: 601434 Tail Gene (2) Alignment: HSPB1 | OMIM: 602195 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
65005-13416102513417400151oncogene33157+763026997630280731oncogene 365 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
HSP20 (PF00011, IPR002068) 101 183 280 5.7e-29 86.600 Hsp20/alpha crystallin family
Updated: 2019-02-20
Owner: ChiTaRS
NM_170679.2		2..257
100.0%		-
5
NM_001540.4		257..365
100.0%		+
7		1
0
0		exon-exon
4
Homo Sapiens		 ChimerDB

ANNOTATION OF CHIMERA FUSION

GenBank ID: AA903814 FASTA
Head Gene (1) Alignment: HSPB1 | OMIM: 602195 Tail Gene (2) Alignment: EGR1 | OMIM: 128990 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
33157-763042167630429431oncogene19585-13846601713846683921oncogene,
tumor suppressor		 212 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
HSP20 (PF00011, IPR002068) 101 365 434 2e-16 46.300 Hsp20/alpha crystallin family
DUF3432 (PF11914, IPR021839) 98 570 617 0.059 0.000 Domain of unknown function (DUF3432)
DUF3446 (PF11928, IPR021849) 88 605 689 1.6e-28 85.200 Domain of unknown function (DUF3446)
zf-C2H2 (PF00096, IPR007087, SM00355) 23 808 832 5.3e-09 22.700 Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087) 26 824 849 4e-11 29.400 Zinc-finger double domain
Updated: 2019-02-17
Owner: ChiTaRS
NM_001540.4		7..85
100.0%		-
7
NM_001964.2		77..212
99.3%		-
5		1
0
0		exon-exon
5
Homo Sapiens		 ChimerDB

ANNOTATION OF CHIMERA FUSION

GenBank ID: BU737515 FASTA
Head Gene (1) Alignment: HSPB1 | OMIM: 602195 Tail Gene (2) Alignment: PTRH1 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
33157-763042207630429531oncogene1384289-12769182512769214960protein-coding 413 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
HSP20 (PF00011, IPR002068) 101 95 152 6.7e-10 25.400 Hsp20/alpha crystallin family
Updated: 2019-02-21
Owner: ChiTaRS
NM_001540.4		19..94
97.4%		-
7
XR_002956760.1		89..413
97.9%		-
9		1
0
0		exon-intron
6
Homo Sapiens		 ChimerDB

ANNOTATION OF CHIMERA FUSION

GenBank ID: N36356 FASTA
Head Gene (1) Alignment: RMRP | OMIM: 157660 Tail Gene (2) Alignment: HSPB1 | OMIM: 602195 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
60239-356577563565800611oncogene33157+763029197630403631oncogene 529 hg38
Updated: 2019-02-21
Owner: ChiTaRS
RMRP
NR_003051.3		2..252
95.5%		-
9
NM_001540.4		249..529
96.4%		+
7		1
0
0		exon-exon
7
Homo Sapiens		 ChimerDB

ANNOTATION OF CHIMERA FUSION

GenBank ID: CD387519 FASTA
Head Gene (1) Alignment: HSPB1 | OMIM: 602195 Tail Gene (2) Alignment: UBE2M | OMIM: 603173 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
33157+763026737630287711oncogene904019-585560005855843461protein-coding 959 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
UQ_con (PF00179, IPR000608) 140 118 253 2.1e-43 133.600 Ubiquitin-conjugating enzyme
Updated: 2019-02-21
Owner: ChiTaRS
NM_001540.4		24..228
100.0%		+
7
NM_003969.3		226..934
98.6%		-
19		1
0
0		exon-exon
8
Homo Sapiens		 ChimerDB

ANNOTATION OF CHIMERA FUSION

GenBank ID: R77849 FASTA
Head Gene (1) Alignment: GJC1 | OMIM: 608655 Tail Gene (2) Alignment: HSPB1 | OMIM: 602195 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
1005217-448014064480162811protein-coding33157+763042187630429511oncogene 345 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
Connexin (PF00029, IPR013092, SM00037) 226 92 345 2.2e-102 327.700 Connexin
Updated: 2019-02-21
Owner: ChiTaRS
XM_024450527.1		1..224
98.7%		-
17
NM_001540.4		220..298
96.2%		+
7		1
0
0		exon-exon
9
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: Z23090 FASTA
UniProtKB: P04792 Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Stress-responsive protein 27) (SRP27)
Fusion Gene(s): HSPB1 HSP27 HSP28
Head Gene (1) Alignment: RPS2P48 Tail Gene (2) Alignment: HSPB1 | OMIM: 602195 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
64517317-537570315375705511pseudo33157+763026997630429531oncogene 1231 hg38
Updated: 2019-02-21
Owner: ChiTaRS
RPS2P48 460..484
100.0%		-
17
NM_001540.4		478..1231
100.0%		+
7		1
0
0		exon-exon
10
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: AI801539 FASTA
Head Gene (1) Alignment: HSPB1P1 Tail Gene (2) Alignment: HSPB1 | OMIM: 602195 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
6535539+720077437200791411pseudo33157+763027547630307731oncogene 565 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
HSP20 (PF00011, IPR002068) 101 87 184 1.2e-28 85.600 Hsp20/alpha crystallin family
Updated: 2019-02-02
Owner: ChiTaRS
HSPB1P1 1..169
95.3%		+
9
NM_001540.4		165..488
97.9%		+
7		15
222
11		exon-exon

T o p