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Rank: Junction Consistence: Hi-C Sense-ANTIsense

Mass-spec hits Read-through chimeras Breakpoints RNAseq evidence
UniProtKB hits
Organisms
Homo Sapiens Mus musculus D.Melanogaster
Rattus Norvegicus Bos Taurus Danio Rerio
Saccharomyces Cerevisiae Sus ScrofaAll organisms

Result for the search of Gene Name/NCBI ID(s): 'AFDN'

Total of fusion sequences: 19 (from 10,657,267 parsed EST/mRNAs. Last update: 2020-11-05 10:39:19)

Organism Fusion:
Graphical View,
Annotation,
PPI network 		Head Gene (1) Tail Gene (2) Rank,
Deviation:
Eloc(x)
Sloc(y) 		Fusion type RNA Hi-C,
RNAseq,
Mass-spec
evidences		 Cancer
Breakpoint,
PubMed(s)
Name(s)1,
transcript		 Start1..End1
Ident1% 		Strand1
Chrom1 		Name(s)2,
transcript		 Start2..End2
Ident2% 		Strand2
Chrom2
1234,5,67,1989,10,1112,2513,14,15321617
1
Homo Sapiens		 ChimerDB

ANNOTATION OF CHIMERA FUSION

GenBank ID: BX101569 FASTA
Head Gene (1) Alignment: AFDN | OMIM: 159559 Tail Gene (2) Alignment: TMEM151B Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
43016-167964633167965036301oncogene,
protein-coding		4411516-442787754427886511protein-coding 504 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
DIL (PF01843, IPR018444, SM01132) 104 315 419 6.5e-35 105.900 DIL domain
PDZ (PF00595, IPR001478, SM00228) 82 538 620 9.9e-21 60.300 PDZ domain (Also known as DHR or GLGF)
Pex14_N (PF04695, IPR006785) 151 691 802 0.059 0.300 Peroxisomal membrane anchor protein (Pex14p) conserved region
Pap_E4 (PF02711, IPR003861) 95 733 810 0.023 2.100 E4 protein
VIR_N (PF15912, IPR031801) 259 881 979 0.0086 1.800 Virilizer, N-terminal
ARGLU (PF15346) 151 926 1015 0.00041 6.500 Arginine and glutamate-rich 1
CYYR1 (PF10873, IPR022640) 149 1857 1890 0.0035 4.000 Cysteine and tyrosine-rich protein 1
Updated: 2019-02-21
Owner: ChiTaRS
NM_001040000.2		14..417
100.0%		-
6		 TMEM151B
Q8IW70
NM_001137560.1		414..504
100.0%		-
6		1
0
0		exon-exon
2
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: DQ387206 FASTA
UniProtKB: Q1WD23 MLL/AF6 fusion protein (Fragment)
Fusion Gene(s): MLL/AF6 fusion
Head Gene (1) Alignment: KMT2A | OMIM: 159555 Tail Gene (2) Alignment: AFDN | OMIM: 159559 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
429711+118482457118484315101oncogene,
protein-coding		43016+167864544167864746341oncogene,
protein-coding		 379 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
Secretin_N_2 (PF07655, IPR011514) 95 61 109 0.031 1.200 Secretin N-terminal domain
YL1 (PF05764, IPR008895) 242 81 229 0.021 1.000 YL1 nuclear protein
AT_hook (PF02178, IPR017956, SM00384) 13 219 227 0.0021 4.700 AT hook motif
Ribosomal_60s (PF00428, IPR001813) 88 367 420 0.013 2.400 60s Acidic ribosomal protein
Vfa1 (PF08432, IPR013640) 181 428 571 0.00046 6.700 AAA-ATPase Vps4-associated protein 1
DUF3915 (PF13054, IPR025026) 123 856 909 0.00017 7.900 Protein of unknown function (DUF3915)
SR-25 (PF10500, IPR019532) 227 978 1082 0.0037 3.000 Nuclear RNA-splicing-associated protein
zf-CXXC (PF02008, IPR002857) 48 1147 1194 1.8e-17 49.500 CXXC zinc finger domain
DUF755 (PF05501, IPR008474) 123 1170 1262 0.025 1.100 Domain of unknown function (DUF755)
RA (PF00788, IPR000159, SM00314) 93 1410 1504 9.8e-25 73.400 Ras association (RalGDS/AF-6) domain
MAS20 (PF02064, IPR002056) 129 1520 1630 0.00013 8.300 MAS20 protein import receptor
DUF788 (PF05620, IPR008506) 167 1569 1605 0.0082 2.200 Protein of unknown function (DUF788)
FHA (PF00498, IPR000253, SM00240) 69 1796 1862 1e-10 28.100 FHA domain
DIL (PF01843, IPR018444, SM01132) 104 2155 2259 9.1e-35 105.400 DIL domain
PDZ (PF00595, IPR001478, SM00228) 82 2378 2460 1.4e-20 59.800 PDZ domain (Also known as DHR or GLGF)
Pex14_N (PF04695, IPR006785) 151 2653 2754 0.0013 5.700 Peroxisomal membrane anchor protein (Pex14p) conserved region
NARP1 (PF12569, IPR021183) 515 2756 2855 0.0028 2.600 NMDA receptor-regulated protein 1
DUF1777 (PF08648, IPR013957) 171 2984 3199 0.00013 8.500 Protein of unknown function (DUF1777)
Updated: 2019-02-21
Owner: ChiTaRS
XM_011542829.2		1..172
100.0%		+
11
XM_017010886.1		165..367
99.6%		+
6		3
0
0		exon-exon2RNA-seq
BREAKPOINTs
3
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: HE805693 FASTA
Head Gene (1) Alignment: KMT2A | OMIM: 159555 Tail Gene (2) Alignment: AFDN | OMIM: 159559 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
429711+118498689118499142230oncogene,
protein-coding		43016+167829407167829626340oncogene,
protein-coding		 674 hg38
Updated: 2019-02-21
Owner: ChiTaRS
XM_011542829.2		1..454
100.0%		+
11
XM_017010886.1		455..674
100.0%		+
6		0
15612
20073		intron-intron2RNA-seq
BREAKPOINTs
4
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: S82519 FASTA
Head Gene (1) Alignment: KMT2A | OMIM: 159555 Tail Gene (2) Alignment: AFDN | OMIM: 159559 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
429711+11848206811848209381oncogene,
protein-coding		43016+167864549167864594341oncogene,
protein-coding		 69 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
RA (PF00788, IPR000159, SM00314) 93 1236 1276 0.055 0.500 Ras association (RalGDS/AF-6) domain
MAS20 (PF02064, IPR002056) 129 1451 1561 0.00013 8.400 MAS20 protein import receptor
FHA (PF00498, IPR000253, SM00240) 69 1727 1793 1e-10 28.200 FHA domain
DIL (PF01843, IPR018444, SM01132) 104 2086 2190 8.9e-35 105.500 DIL domain
PDZ (PF00595, IPR001478, SM00228) 82 2309 2391 1.3e-20 59.800 PDZ domain (Also known as DHR or GLGF)
Pap_E4 (PF02711, IPR003861) 95 2503 2580 0.038 1.400 E4 protein
Pex14_N (PF04695, IPR006785) 151 2584 2685 0.0012 5.700 Peroxisomal membrane anchor protein (Pex14p) conserved region
NARP1 (PF12569, IPR021183) 515 2687 2786 0.0027 2.600 NMDA receptor-regulated protein 1
Peptidase_S49_N (PF08496, IPR013703) 153 2889 2980 0.026 0.800 Peptidase family S49 N-terminal
DUF1777 (PF08648, IPR013957) 171 2915 3131 0.00013 8.400 Protein of unknown function (DUF1777)
Updated: 2019-02-21
Owner: ChiTaRS
XM_011542829.2		1..26
100.0%		+
11
XM_017010886.1		24..69
100.0%		+
6		3
403
0		exon-exon2RNA-seq
BREAKPOINTs
5
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: S82521 FASTA
Head Gene (1) Alignment: KMT2A | OMIM: 159555 Tail Gene (2) Alignment: AFDN | OMIM: 159559 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
429711+11848247211848249691oncogene,
protein-coding		43016+167864549167864595341oncogene,
protein-coding		 69 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
DUF4519 (PF15012, IPR027960) 56 522 569 0.00025 7.500 Domain of unknown function (DUF4519)
RA (PF00788, IPR000159, SM00314) 93 1229 1323 9.2e-25 73.500 Ras association (RalGDS/AF-6) domain
MAS20 (PF02064, IPR002056) 129 1339 1449 0.00012 8.400 MAS20 protein import receptor
FHA (PF00498, IPR000253, SM00240) 69 1615 1681 9.8e-11 28.200 FHA domain
DIL (PF01843, IPR018444, SM01132) 104 1974 2078 8.5e-35 105.500 DIL domain
PDZ (PF00595, IPR001478, SM00228) 82 2197 2279 1.3e-20 59.900 PDZ domain (Also known as DHR or GLGF)
Pap_E4 (PF02711, IPR003861) 95 2392 2469 0.031 1.700 E4 protein
Pex14_N (PF04695, IPR006785) 151 2472 2573 0.0012 5.800 Peroxisomal membrane anchor protein (Pex14p) conserved region
ARGLU (PF15346) 151 2585 2674 0.00053 6.100 Arginine and glutamate-rich 1
Peptidase_S49_N (PF08496, IPR013703) 153 2777 2868 0.025 0.900 Peptidase family S49 N-terminal
DUF1777 (PF08648, IPR013957) 171 2803 3019 0.00013 8.400 Protein of unknown function (DUF1777)
Updated: 2019-02-21
Owner: ChiTaRS
XM_011542829.2		1..25
100.0%		+
11
XM_017010886.1		23..69
100.0%		+
6		3
403
0		exon-exon2RNA-seq
BREAKPOINTs
6
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: S82517 FASTA
Head Gene (1) Alignment: KMT2A | OMIM: 159555 Tail Gene (2) Alignment: AFDN | OMIM: 159559 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
429711+118484291118484315101oncogene,
protein-coding		43016+167864544167864595341oncogene,
protein-coding		 69 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
Secretin_N_2 (PF07655, IPR011514) 95 61 109 0.031 1.200 Secretin N-terminal domain
YL1 (PF05764, IPR008895) 242 81 229 0.021 1.000 YL1 nuclear protein
AT_hook (PF02178, IPR017956, SM00384) 13 219 227 0.0021 4.700 AT hook motif
Ribosomal_60s (PF00428, IPR001813) 88 367 420 0.013 2.400 60s Acidic ribosomal protein
Vfa1 (PF08432, IPR013640) 181 428 571 0.00046 6.700 AAA-ATPase Vps4-associated protein 1
DUF3915 (PF13054, IPR025026) 123 856 909 0.00017 7.900 Protein of unknown function (DUF3915)
SR-25 (PF10500, IPR019532) 227 978 1082 0.0037 3.000 Nuclear RNA-splicing-associated protein
zf-CXXC (PF02008, IPR002857) 48 1147 1194 1.8e-17 49.500 CXXC zinc finger domain
DUF755 (PF05501, IPR008474) 123 1170 1262 0.025 1.100 Domain of unknown function (DUF755)
RA (PF00788, IPR000159, SM00314) 93 1410 1504 9.8e-25 73.400 Ras association (RalGDS/AF-6) domain
MAS20 (PF02064, IPR002056) 129 1520 1630 0.00013 8.300 MAS20 protein import receptor
DUF788 (PF05620, IPR008506) 167 1569 1605 0.0082 2.200 Protein of unknown function (DUF788)
FHA (PF00498, IPR000253, SM00240) 69 1796 1862 1e-10 28.100 FHA domain
DIL (PF01843, IPR018444, SM01132) 104 2155 2259 9.1e-35 105.400 DIL domain
PDZ (PF00595, IPR001478, SM00228) 82 2378 2460 1.4e-20 59.800 PDZ domain (Also known as DHR or GLGF)
Pex14_N (PF04695, IPR006785) 151 2653 2754 0.0013 5.700 Peroxisomal membrane anchor protein (Pex14p) conserved region
NARP1 (PF12569, IPR021183) 515 2756 2855 0.0028 2.600 NMDA receptor-regulated protein 1
DUF1777 (PF08648, IPR013957) 171 2984 3199 0.00013 8.500 Protein of unknown function (DUF1777)
Updated: 2019-02-22
Owner: ChiTaRS
XM_011542829.2		1..25
100.0%		+
11
XM_017010886.1		18..69
98.1%		+
6		3
0
0		exon-exon2RNA-seq
BREAKPOINTs
7
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: AY288776 FASTA
Head Gene (1) Alignment: AFDN | OMIM: 159559 Tail Gene (2) Alignment: KMT2A | OMIM: 159555 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
43016+167849480167919518210oncogene,
protein-coding		429711+118483392118483530280oncogene,
protein-coding		 311 hg38
Updated: 2019-02-20
Owner: ChiTaRS
XM_017010886.1		1..179
96.2%		+
6
XM_011542829.2		176..311
100.0%		+
11		0
785
15064		intron-intronBREAKPOINTs
8
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: DQ387205 FASTA
Head Gene (1) Alignment: AFDN | OMIM: 159559 Tail Gene (2) Alignment: KMT2A | OMIM: 159555 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
43016+16785944516786018910oncogene,
protein-coding		429711+118484605118484983270oncogene,
protein-coding		 1124 hg38
Updated: 2019-02-21
Owner: ChiTaRS
XM_017010886.1		1..745
100.0%		+
6
XM_011542829.2		746..1124
99.5%		+
11		0
668
5099		intron-intronBREAKPOINTs
9
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: CB050783 FASTA
Head Gene (1) Alignment: PLA2G2A | OMIM: 172411 Tail Gene (2) Alignment: AFDN | OMIM: 159559 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
53201+199754351997550111oncogene,
tumor suppressor,
protein-coding		43016-16795168316795208661oncogene,
protein-coding		 496 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
TFIIA (PF03153, IPR004855) 415 586 847 0.0027 3.800 Transcription factor IIA, alpha/beta subunit
DDRGK (PF09756, IPR019153, SM01128) 188 767 839 0.013 1.300 DDRGK domain
Ribosomal_60s (PF00428, IPR001813) 88 905 948 0.061 0.200 60s Acidic ribosomal protein
Updated: 2019-02-21
Owner: ChiTaRS
NM_000300.3		23..89
100.0%		+
1
XM_017010886.1		85..488
100.0%		-
6		3
0
10		exon-exon
10
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: BE646307 FASTA
Head Gene (1) Alignment: PLA2G2A | OMIM: 172411 Tail Gene (2) Alignment: AFDN | OMIM: 159559 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
53201+199754361997550111oncogene,
tumor suppressor,
protein-coding		43016-16795171716795208661oncogene,
protein-coding		 431 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
Afi1 (PF07792, IPR012860) 133 645 752 0.012 2.400 Docking domain of Afi1 for Arf3 in vesicle trafficking
Peptidase_S49_N (PF08496, IPR013703) 153 718 811 0.0062 2.800 Peptidase family S49 N-terminal
Ribosomal_60s (PF00428, IPR001813) 88 883 925 0.035 1.000 60s Acidic ribosomal protein
Updated: 2019-02-20
Owner: ChiTaRS
NM_000300.3		1..66
98.5%		+
1
XM_017010886.1		62..431
100.0%		-
6		3
0
0		exon-exon

T O P