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Rank: Junction Consistence: Hi-C Sense-ANTIsense

Mass-spec hits Read-through chimeras Breakpoints RNAseq evidence
UniProtKB hits
Organisms
Homo Sapiens Mus musculus D.Melanogaster
Rattus Norvegicus Bos Taurus Danio Rerio
Saccharomyces Cerevisiae Sus ScrofaAll organisms

Result for the search of Gene Name/NCBI ID(s): 'ABL1'

Total of fusion sequences: 221 (from 1,493,742 parsed EST/mRNAs. Last update: 2019-12-05 16:32:10)

Organism Fusion:
Graphical View,
Annotation,
PPI network 		Head Gene (1) Tail Gene (2) Rank,
Deviation:
Eloc(x)
Sloc(y) 		Fusion type RNA Hi-C,
RNAseq,
Mass-spec
evidences		 Cancer
Breakpoint,
PubMed(s)
Name(s)1,
transcript		 Start1..End1
Ident1% 		Strand1
Chrom1 		Name(s)2,
transcript		 Start2..End2
Ident2% 		Strand2
Chrom2
1234,5,67,1989,10,1112,2513,14,15321617
1
Homo Sapiens		SplGraphs

ANNOTATION OF CHIMERA FUSION

GenBank ID: AM491362 FASTA
UniProtKB: A2RQD6 Bcr-abl1 e6a2 chimeric protein (Fragment)
Fusion Gene(s): BCR-ABL1
Head Gene (1) Alignment: BCR | OMIM: 151410 Tail Gene (2) Alignment: ABL1 | OMIM: 189980 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
61322+231817852327159261oncogene,
protein-coding		259+130854064130862953101oncogene,
protein-coding		 1758 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
Bcr-Abl_Oligo (PF09036, IPR015123) 73 3 75 7.5e-44 134.000 Bcr-Abl oncoprotein oligomerisation domain
RhoGEF (PF00621, IPR000219, SM00325) 181 502 648 9.1e-21 61.100 RhoGEF domain
SH3_1 (PF00018, IPR001452, SM00326) 48 681 727 2.7e-16 45.300 SH3 domain
SH2 (PF00017, IPR000980, SM00252) 77 741 816 2.6e-27 81.100 SH2 domain
Pkinase_Tyr (PF07714, IPR001245) 260 856 1107 5.6e-103 329.800 Protein tyrosine kinase
FRG2 (PF15315, IPR026245) 184 1299 1432 5.4e-05 9.600 Facioscapulohumeral muscular dystrophy candidate 2
F_actin_bind (PF08919, IPR015015, SM00808) 110 1639 1744 4.3e-32 96.800 F-actin binding
Updated: 2019-02-02
Owner: ChiTaRS
NM_004327.3		1..1097
100.0%		+
22
NM_005157.5		1098..1758
99.9%		+
9		0
18029
2		exon-exon7RNA-seq
BREAKPOINTs
more info
2
Homo Sapiens		SplGraphs

ANNOTATION OF CHIMERA FUSION

GenBank ID: EU216064 FASTA
UniProtKB: A9UF00 BCR/ABL fusion protein isoform X7
Fusion Gene(s): BCR/ABL fusion
Head Gene (1) Alignment: BCR | OMIM: 151410 Tail Gene (2) Alignment: ABL1 | OMIM: 189980 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
61322+231809612326099231oncogene,
protein-coding		259+130854153130854225101oncogene,
protein-coding		 1575 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
SH3_1 (PF00018, IPR001452, SM00326) 48 511 557 2.4e-16 45.400 SH3 domain
SH2 (PF00017, IPR000980, SM00252) 77 571 646 2.3e-27 81.200 SH2 domain
Pkinase_Tyr (PF07714, IPR001245) 260 686 937 4.8e-103 330.000 Protein tyrosine kinase
FRG2 (PF15315, IPR026245) 184 1129 1262 4.7e-05 9.800 Facioscapulohumeral muscular dystrophy candidate 2
F_actin_bind (PF08919, IPR015015, SM00808) 110 1469 1574 3.8e-32 97.000 F-actin binding
Updated: 2019-02-02
Owner: ChiTaRS
NM_004327.3		1..1504
100.0%		+
22
NM_005157.5		1503..1575
100.0%		+
9		0
7007
3		exon-exon7RNA-seq
BREAKPOINTs
more info
3
Homo Sapiens		SplGraphs

ANNOTATION OF CHIMERA FUSION

GenBank ID: DQ912589 FASTA
UniProtKB: A6MFJ8 BCR/ABL fusion protein e13a5 (Fragment)
Fusion Gene(s): BCR/ABL fusion
Head Gene (1) Alignment: BCR | OMIM: 151410 Tail Gene (2) Alignment: ABL1 | OMIM: 189980 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
61322+2328951723289622131oncogene,
protein-coding		259+13087212713087219671oncogene,
protein-coding		 178 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
Bcr-Abl_Oligo (PF09036, IPR015123) 73 3 75 7.5e-44 134.000 Bcr-Abl oncoprotein oligomerisation domain
RhoGEF (PF00621, IPR000219, SM00325) 181 502 689 2.5e-38 118.300 RhoGEF domain
PH (PF00169, IPR001849, SM00233) 105 701 866 1.1e-06 15.400 PH domain
IQ_SEC7_PH (PF16453, IPR001849) 138 706 802 9.8e-07 15.100 PH domain
Updated: 2019-02-02
Owner: ChiTaRS
NM_004327.3		6..111
100.0%		+
22
NM_005157.5		109..178
100.0%		+
9		57
792
2		exon-exon7RNA-seq
BREAKPOINTs
more info
4
Homo Sapiens		SplGraphs

ANNOTATION OF CHIMERA FUSION

GenBank ID: DQ912590 FASTA
UniProtKB: A6MFJ9 BCR/ABL fusion protein e14a5 (Fragment)
Fusion Gene(s): BCR/ABL fusion
Head Gene (1) Alignment: BCR | OMIM: 151410 Tail Gene (2) Alignment: ABL1 | OMIM: 189980 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
61322+2328951723290414141oncogene,
protein-coding		259+13087212913087219671oncogene,
protein-coding		 253 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
Bcr-Abl_Oligo (PF09036, IPR015123) 73 3 75 7.7e-44 134.000 Bcr-Abl oncoprotein oligomerisation domain
RhoGEF (PF00621, IPR000219, SM00325) 181 502 689 2.6e-38 118.200 RhoGEF domain
PH (PF00169, IPR001849, SM00233) 105 701 866 1.1e-06 15.400 PH domain
IQ_SEC7_PH (PF16453, IPR001849) 138 706 802 1e-06 15.000 PH domain
Updated: 2019-02-02
Owner: ChiTaRS
NM_004327.3		6..186
100.0%		+
22
NM_005157.5		186..253
100.0%		+
9		0
131
9371		exon-exon7RNA-seq
BREAKPOINTs
more info
5
Homo Sapiens		SplGraphs

ANNOTATION OF CHIMERA FUSION

GenBank ID: EF423615 FASTA
UniProtKB: A3RL30 BCR/ABL fusion protein (Fragment)
Fusion Gene(s): BCR/ABL fusion
Head Gene (1) Alignment: BCR | OMIM: 151410 Tail Gene (2) Alignment: ABL1 | OMIM: 189980 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
61322+232881522328959221oncogene,
protein-coding		259+13085406413085484721oncogene,
protein-coding		 324 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
Bcr-Abl_Oligo (PF09036, IPR015123) 73 3 75 8.7e-44 133.800 Bcr-Abl oncoprotein oligomerisation domain
RhoGEF (PF00621, IPR000219, SM00325) 181 502 689 3e-38 118.000 RhoGEF domain
PH (PF00169, IPR001849, SM00233) 105 701 866 1.2e-06 15.300 PH domain
IQ_SEC7_PH (PF16453, IPR001849) 138 706 802 1.1e-06 14.900 PH domain
SH3_1 (PF00018, IPR001452, SM00326) 48 933 979 3.1e-16 45.100 SH3 domain
SH2 (PF00017, IPR000980, SM00252) 77 993 1068 3e-27 80.800 SH2 domain
Pkinase_Tyr (PF07714, IPR001245) 260 1108 1359 6.8e-103 329.500 Protein tyrosine kinase
FRG2 (PF15315, IPR026245) 184 1551 1683 8.9e-05 8.900 Facioscapulohumeral muscular dystrophy candidate 2
F_actin_bind (PF08919, IPR015015, SM00808) 110 1891 1996 5e-32 96.600 F-actin binding
Updated: 2019-06-02
Owner: ChiTaRS
NM_004327.3		7..103
100.0%		+
22
NM_007313.2		103..323
100.0%		+
9		57
29
2		exon-exon7RNA-seq
BREAKPOINTs
more info
6
Homo Sapiens		SplGraphs

ANNOTATION OF CHIMERA FUSION

GenBank ID: DQ912588 FASTA
UniProtKB: A6MFJ7 BCR/ABL fusion protein e1a5 (Fragment)
Fusion Gene(s): BCR/ABL fusion
Head Gene (1) Alignment: BCR | OMIM: 151410 Tail Gene (2) Alignment: ABL1 | OMIM: 189980 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
61322+231820742318224011oncogene,
protein-coding		259+13087212513087219671oncogene,
protein-coding		 234 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
Pkinase_Tyr (PF07714, IPR001245) 260 420 645 2e-92 295.200 Protein tyrosine kinase
F_actin_bind (PF08919, IPR015015, SM00808) 110 1177 1282 2.9e-32 97.300 F-actin binding
Updated: 2019-02-02
Owner: ChiTaRS
NM_004327.3		1..167
100.0%		+
22
NM_005157.5		163..234
100.0%		+
9		0
1
9365		exon-exon7RNA-seq
BREAKPOINTs
more info
7
Homo Sapiens		SplGraphs

ANNOTATION OF CHIMERA FUSION

GenBank ID: AF487522 FASTA
UniProtKB: Q8TDA2 BCRe18/ABL1e3 fusion protein (Fragment)
Fusion Gene(s): BCR/ABL fusion
Head Gene (1) Alignment: BCR | OMIM: 151410 Tail Gene (2) Alignment: ABL1 | OMIM: 189980 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
61322+2329508723311836191oncogene,
protein-coding		259+130854064130854110101oncogene,
protein-coding		 426 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
Bcr-Abl_Oligo (PF09036, IPR015123) 73 3 75 9.8e-44 133.600 Bcr-Abl oncoprotein oligomerisation domain
RhoGEF (PF00621, IPR000219, SM00325) 181 502 689 3.4e-38 117.800 RhoGEF domain
PH (PF00169, IPR001849, SM00233) 105 701 866 1.4e-06 15.100 PH domain
IQ_SEC7_PH (PF16453, IPR001849) 138 706 802 1.3e-06 14.700 PH domain
C2 (PF00168, IPR000008, SM00239) 103 911 1017 6e-10 25.700 C2 domain
RhoGAP (PF00620, IPR000198, SM00324) 152 1068 1128 4.3e-14 38.800 RhoGAP domain
SH3_1 (PF00018, IPR001452, SM00326) 48 1148 1194 3.5e-16 44.900 SH3 domain
SH2 (PF00017, IPR000980, SM00252) 77 1208 1283 3.4e-27 80.700 SH2 domain
Pkinase_Tyr (PF07714, IPR001245) 260 1323 1574 7.8e-103 329.300 Protein tyrosine kinase
FRG2 (PF15315, IPR026245) 184 1766 1898 0.0001 8.700 Facioscapulohumeral muscular dystrophy candidate 2
F_actin_bind (PF08919, IPR015015, SM00808) 110 2106 2211 5.7e-32 96.400 F-actin binding
Updated: 2019-02-02
Owner: ChiTaRS
NM_004327.3		1..379
100.0%		+
22
NM_005157.5		380..426
100.0%		+
9		57
0
0		exon-exon7RNA-seq
BREAKPOINTs
more info
8
Homo Sapiens		SplGraphs

ANNOTATION OF CHIMERA FUSION

GenBank ID: AM491360 FASTA
UniProtKB: A2RQD4 Bcr-abl1 e14a3 chimeric protein (Fragment)
Fusion Gene(s): BCR-ABL1
Head Gene (1) Alignment: BCR | OMIM: 151410 Tail Gene (2) Alignment: ABL1 | OMIM: 189980 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
61322+2328724023290415141oncogene,
protein-coding		259+13085480113086295391oncogene,
protein-coding		 782 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
Bcr-Abl_Oligo (PF09036, IPR015123) 73 3 75 8.6e-44 133.800 Bcr-Abl oncoprotein oligomerisation domain
RhoGEF (PF00621, IPR000219, SM00325) 181 502 689 2.9e-38 118.100 RhoGEF domain
PH (PF00169, IPR001849, SM00233) 105 701 866 1.2e-06 15.200 PH domain
IQ_SEC7_PH (PF16453, IPR001849) 138 706 802 1.1e-06 14.900 PH domain
SH3_3 (PF08239, IPR003646) 55 926 960 8.6e-07 15.500 Bacterial SH3 domain
SH2 (PF00017, IPR000980, SM00252) 77 970 1045 3e-27 80.900 SH2 domain
Pkinase_Tyr (PF07714, IPR001245) 260 1085 1336 6.6e-103 329.600 Protein tyrosine kinase
FRG2 (PF15315, IPR026245) 184 1528 1660 8.8e-05 8.900 Facioscapulohumeral muscular dystrophy candidate 2
F_actin_bind (PF08919, IPR015015, SM00808) 110 1868 1973 5e-32 96.600 F-actin binding
Updated: 2019-02-02
Owner: ChiTaRS
NM_004327.3		1..297
100.0%		+
22
NM_005157.5		296..782
100.0%		+
9		57
0
0		exon-exon7RNA-seq
BREAKPOINTs
more info