Search Database Collection

 

Choose parameters to search by

Updates:

Search filters
Rank: Junction Consistence: Hi-C Sense-ANTIsense

Mass-spec hits Read-through chimeras Breakpoints RNAseq evidence
UniProtKB hits
Organisms
Homo Sapiens Mus musculus D.Melanogaster
Rattus Norvegicus Bos Taurus Danio Rerio
Saccharomyces Cerevisiae Sus ScrofaAll organisms

Result for the search of Gene Name/NCBI ID(s): '5914,5371'

Total of fusion sequences: 21 (from 1493742 parsed EST/mRNAs. Last update 2019-12-11 12:04:16)

Organism Fusion:
Graphical View,
Annotation,
PPI network 		Head Gene (1) Tail Gene (2) Rank,
Deviation:
Eloc(x)
Sloc(y) 		Fusion type RNA Hi-C,
RNAseq,
Mass-spec
evidences		 Cancer
Breakpoint,
PubMed(s)
Name(s)1,
transcript		 Start1..End1
Ident1% 		Strand1
Chrom1 		Name(s)2,
transcript		 Start2..End2
Ident2% 		Strand2
Chrom2
1234,5,67,1989,10,1112,2513,14,15321617
1
Homo Sapiens		SplGraphs

ANNOTATION OF CHIMERA FUSION

GenBank ID: M73779 FASTA
UniProtKB: Q15156 PML-RAR protein
Fusion Gene(s): PML-RAR
Head Gene (1) Alignment: PML | OMIM: 102578 Tail Gene (2) Alignment: RARA | OMIM: 180240 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
537115+739947477402340831oncogene,
tumor suppressor		591417+403483144035679471oncogene 3036 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
Prok-RING_4 (PF14447) 46 79 117 2.3e-07 16.900 Prokaryotic RING finger family 4
zf-RING_UBOX (PF13445, IPR027370) 38 110 126 0.025 1.000 RING-type zinc-finger
zf-B_box (PF00643, IPR000315, SM00336) 42 146 188 4e-12 32.500 B-box zinc finger
DUF3583 (PF12126, IPR021978) 329 262 439 1.4e-94 303.200 Protein of unknown function (DUF3583)
zf-C4 (PF00105, IPR001628, SM00399) 70 443 512 2.1e-36 110.500 Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430) 208 581 758 1.1e-26 79.800 Ligand-binding domain of nuclear hormone receptor
Updated: 2019-02-02
Owner: ChiTaRS
NM_033238.2		1..1249
100.0%		+
15
XM_011525095.1		1248..3028
100.0%		+
17		0
535
38628		exon-exonBREAKPOINTs
more info
2
Homo Sapiens		SplGraphs

ANNOTATION OF CHIMERA FUSION

GenBank ID: M82827 FASTA
Head Gene (1) Alignment: RARA | OMIM: 180240 Tail Gene (2) Alignment: PML | OMIM: 102578 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
591417+403308944033139631oncogene537115+740248577403637161oncogene,
tumor suppressor		 2253 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
DUF3583 (PF12126, IPR021978) 329 343 364 1.5e-07 17.200 Protein of unknown function (DUF3583)
Updated: 2019-02-02
Owner: ChiTaRS
XM_011525095.1		1..502
100.0%		+
17
NM_033238.2		503..2093
99.9%		+
15		0
17009
1479		exon-exonBREAKPOINTs
more info
3
Homo Sapiens		SplGraphs

ANNOTATION OF CHIMERA FUSION

GenBank ID: S50916 FASTA
Head Gene (1) Alignment: PML | OMIM: 102578 Tail Gene (2) Alignment: RARA | OMIM: 180240 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
537115+740333757403341461oncogene,
tumor suppressor		591417+403483144035625971oncogene 1284 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
Prok-RING_4 (PF14447) 46 57 95 2.2e-07 17.000 Prokaryotic RING finger family 4
zf-RING_UBOX (PF13445, IPR027370) 38 88 104 0.023 1.100 RING-type zinc-finger
zf-B_box (PF00643, IPR000315, SM00336) 42 124 166 3.8e-12 32.500 B-box zinc finger
DUF3583 (PF12126, IPR021978) 329 240 564 9.9e-174 563.400 Protein of unknown function (DUF3583)
zf-C4 (PF00105, IPR001628, SM00399) 70 579 648 2e-36 110.600 Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430) 208 717 894 1.1e-26 79.900 Ligand-binding domain of nuclear hormone receptor
Updated: 2019-02-02
Owner: ChiTaRS
NM_033238.2		1..40
100.0%		+
15
XM_011525095.1		39..1284
100.0%		+
17		0
8076
29		exon-exonBREAKPOINTs
more info
4
Homo Sapiens		SplGraphs

ANNOTATION OF CHIMERA FUSION

GenBank ID: AJ417079 FASTA
Head Gene (1) Alignment: PML | OMIM: 102578 Tail Gene (2) Alignment: RARA | OMIM: 180240 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
537115+740331567403327561oncogene,
tumor suppressor		591417+403428044034843981oncogene 296 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
Prok-RING_4 (PF14447) 46 57 95 2.1e-07 17.100 Prokaryotic RING finger family 4
zf-RING_UBOX (PF13445, IPR027370) 38 88 104 0.023 1.100 RING-type zinc-finger
zf-B_box (PF00643, IPR000315, SM00336) 42 124 166 3.6e-12 32.600 B-box zinc finger
DUF3583 (PF12126, IPR021978) 329 240 533 9.2e-150 484.600 Protein of unknown function (DUF3583)
zf-C4 (PF00105, IPR001628, SM00399) 70 550 619 1.9e-36 110.700 Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430) 208 688 865 9.9e-27 80.000 Ligand-binding domain of nuclear hormone receptor
Updated: 2019-02-02
Owner: ChiTaRS
NM_033238.2		1..115
100.0%		+
15
NM_001024809.3		109..296
100.0%		+
17		10
51
719		exon-exonBREAKPOINTs
more info
5
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: AB067754 FASTA
UniProtKB: P10276 Retinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1 group B member 1)
Fusion Gene(s): RARA NR1B1
UniProtKB: P29590 Protein PML (Promyelocytic leukemia protein) (RING finger protein 71) (Tripartite motif-containing protein 19)
Fusion Gene(s): PML MYL PP8675 RNF71 TRIM19
Head Gene (1) Alignment: PML | OMIM: 102578 Tail Gene (2) Alignment: RARA | OMIM: 180240 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
537115+740326767403326861oncogene,
tumor suppressor		591417+403472614034834280oncogene 200 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
Prok-RING_4 (PF14447) 46 57 95 2.1e-07 17.100 Prokaryotic RING finger family 4
zf-RING_UBOX (PF13445, IPR027370) 38 88 104 0.022 1.100 RING-type zinc-finger
zf-B_box (PF00643, IPR000315, SM00336) 42 124 166 3.5e-12 32.600 B-box zinc finger
DUF3583 (PF12126, IPR021978) 329 240 535 2.3e-149 483.300 Protein of unknown function (DUF3583)
zf-C4 (PF00105, IPR001628, SM00399) 70 537 606 1.9e-36 110.700 Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430) 208 675 852 9.6e-27 80.000 Ligand-binding domain of nuclear hormone receptor
Updated: 2019-02-21
Owner: ChiTaRS
NM_033238.2		1..153
100.0%		+
15
XM_017024920.2		153..200
100.0%		+
17		0
24
1102		exon-intronBREAKPOINTs
more info
6
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: M61110 FASTA
Head Gene (1) Alignment: PML | OMIM: 102578 Tail Gene (2) Alignment: RARA | OMIM: 180240 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
537115+740338757403407660oncogene,
tumor suppressor		591417+403479434034849080oncogene 748 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
Prok-RING_4 (PF14447) 46 60 98 3e-07 16.600 Prokaryotic RING finger family 4
zf-RING_UBOX (PF13445, IPR027370) 38 91 107 0.032 0.700 RING-type zinc-finger
zf-B_box (PF00643, IPR000315, SM00336) 42 127 169 5.1e-12 32.100 B-box zinc finger
DUF3583 (PF12126, IPR021978) 329 243 423 1.3e-103 333.000 Protein of unknown function (DUF3583)
Updated: 2019-01-29
Owner: ChiTaRS
NM_033238.2		1..202
99.6%		+
15
XM_017024920.2		202..748
99.9%		+
17		0
1437
1		intron-intronBREAKPOINTs
more info
7
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: S76372 FASTA
Head Gene (1) Alignment: RARA | OMIM: 180240 Tail Gene (2) Alignment: PML | OMIM: 102578 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
591417+403475494034757800oncogene537115+740334067403343111oncogene,
tumor suppressor		 55 hg38
Updated: 2019-03-03
Owner: ChiTaRS
XM_011525095.1		1..30
100.0%		+
17
NM_033238.2		30..55
100.0%		+
15		10
605
2		intron-exonBREAKPOINTs
more info
8
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: S76370 FASTA
Head Gene (1) Alignment: RARA | OMIM: 180240 Tail Gene (2) Alignment: PML | OMIM: 102578 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
591417+403481644034818311oncogene537115+740334047403343911oncogene,
tumor suppressor		 55 hg38
Updated: 2019-03-03
Owner: ChiTaRS
XM_017024920.2		1..20
100.0%		+
17
NM_033238.2		20..55
100.0%		+
15		10
605
2		exon-exonBREAKPOINTs
more info
9
Homo Sapiens

ANNOTATION OF CHIMERA FUSION

GenBank ID: S76373 FASTA
Head Gene (1) Alignment: PML | OMIM: 102578 Tail Gene (2) Alignment: RARA | OMIM: 180240 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
537115+740337787403380500oncogene,
tumor suppressor		591417+403482904034831810oncogene 55 hg38
Updated: 2019-03-03
Owner: ChiTaRS
NM_033238.2		1..28
100.0%		+
15
XM_011525095.1		27..55
100.0%		+
17		10
172
97		intron-intronBREAKPOINTs
more info