Result for the search of Gene Name/NCBI ID(s): '4297,4299'

Total of fusion sequences: 164 (from 1,393,046 parsed EST/mRNAs. Last update 2019-09-04)

Organism	Fusion: Graphical View, Annotation, PPI network	Head Gene (1)			Tail Gene (2)			Rank, Deviation: Eloc(x) Sloc(y)	Fusion type RNA	Hi-C, RNAseq, Mass-spec evidences	Cancer Breakpoint, PubMed(s)
		Name(s)1, transcript	Start1..End1 Ident1%	Strand1 Chrom1	Name(s)2, transcript	Start2..End2 Ident2%	Strand2 Chrom2
1	2	3	4,5,6	7,19	8	9,10,11	12,25	13,14,15	32	16	17
1 Homo Sapiens	SplGraphs DQ451148 ANNOTATION OF CHIMERA FUSION GenBank ID: DQ451148 FASTA UniProtKB: Q0ZHH1 MLL-AF4 fusion protein (Fragment) Head Gene (1) Alignment: KMT2A | OMIM: 159555 Tail Gene (2) Alignment: AFF1 | OMIM: 159557 Qsize UCSC Version Location: exons highlight1 Location: exons highlight2 Entrez GeneID1 chromo- some1 strand1 start_loc1 end_loc1 total1 overlap1 Entrez GeneID2 chromo- some2 strand2 start_loc2 end_loc2 total2 overlap2 18 19 7 20 21 22 23 - 24 25 12 26 27 28 29 - 30 31 4297 11 + 118482042 118482496 9 1 oncogene 4299 4 + 87091791 87094967 15 1 oncogene 215 hg38 Domains of the full fusion Envelope E-value Score Description name (Pfam, InterPro, SMART) length from to Filament_head (PF04732, IPR006821) 87 53 131 0.0086 3.300 Intermediate filament head (DNA binding) region YL1 (PF05764, IPR008895) 242 80 229 0.013 1.700 YL1 nuclear protein AT_hook (PF02178, IPR017956, SM00384) 13 219 227 0.0014 5.200 AT hook motif Ribosomal_60s (PF00428, IPR001813) 88 366 420 0.0079 3.100 60s Acidic ribosomal protein Vfa1 (PF08432, IPR013640) 181 429 571 0.00031 7.300 AAA-ATPase Vps4-associated protein 1 DUF3915 (PF13054, IPR025026) 123 856 909 0.00011 8.400 Protein of unknown function (DUF3915) SR-25 (PF10500, IPR019532) 227 979 1082 0.0024 3.600 Nuclear RNA-splicing-associated protein Stm1_N (PF09598, IPR019084) 65 1107 1159 0.025 1.800 Stm1 zf-CXXC (PF02008, IPR002857) 48 1147 1194 1.2e-17 50.000 CXXC zinc finger domain DUF755 (PF05501, IPR008474) 123 1170 1262 0.016 1.700 Domain of unknown function (DUF755) AF-4 (PF05110, IPR007797) 1227 1349 2180 0 1025.500 AF-4 proto-oncoprotein Updated: 2019-02-02 Owner: ChiTaRS	KMT2A A0A3B3ISN4 A0A3B3ITT0 A0A3B3ITT7 A0A3B3ITZ6 A0A3S6YZ73 A0A4D6WIU0 A0A4D6WLI1 A0A4D6WN96 A0A4D6WQ80 E9PR05 H0YEU4 H7C5V8 H7C5W4 L0R899 Q03164 Q9HBJ4 Q9UBJ5 Q9UM91 Q9UPD0 Q9Y6P1 XM_011542829.2	1..126 100.0%	+ 11	AFF1 D6RAU0 D6RIZ5 E7EMC5 E7ETI4 F5GXF9 H0Y9S4 P51825 Q05D98 Q14C88 Q712L1 XM_005263007.3	124..215 100.0%	+ 4	61 2 214	exon-exon		BREAKPOINTs more info 1423625 1991161 3496135 7579356 7579356 7689231 7689231 7748964 7794749 7827204 8161794 8162575 8180386 8219184 8358709 8378328 8414518 8443374 8506309 8703835 9250788 9680349 9731046 9731046 10416593 10773450 11167741 11420702 11493704 11886378 11930009 11930009 11943339 12750700 12791662 12885467 12972812 15650057 15650057 15650057 16123216 16123216 16424875 16511515 17039234 17039237 17287854 17407135 17410185 17410185 17410185 17889710 19141862 19144982 19459927 20016535 20107154 21354057 21935650 23349309 23628958 24415536 26410102 27265895 27428428 28790105 28790105
2 Homo Sapiens	SplGraphs L22179 ANNOTATION OF CHIMERA FUSION GenBank ID: L22179 FASTA Head Gene (1) Alignment: KMT2A | OMIM: 159555 Tail Gene (2) Alignment: AFF1 | OMIM: 159557 Qsize UCSC Version Location: exons highlight1 Location: exons highlight2 Entrez GeneID1 chromo- some1 strand1 start_loc1 end_loc1 total1 overlap1 Entrez GeneID2 chromo- some2 strand2 start_loc2 end_loc2 total2 overlap2 18 19 7 20 21 22 23 - 24 25 12 26 27 28 29 - 30 31 4297 11 + 118436510 118484314 10 1 oncogene 4299 4 + 87084112 87135701 17 1 oncogene 6940 hg38 Domains of the full fusion Envelope E-value Score Description name (Pfam, InterPro, SMART) length from to Ery_res_leader2 (PF08057, IPR012559) 14 1 12 0.0034 4.700 Erythromycin resistance leader peptide DUF3446 (PF11928, IPR021849) 88 51 121 0.011 2.400 Domain of unknown function (DUF3446) AT_hook (PF02178, IPR017956, SM00384) 13 219 227 0.0037 3.900 AT hook motif Ribosomal_60s (PF00428, IPR001813) 88 367 420 0.023 1.600 60s Acidic ribosomal protein Filament_head (PF04732, IPR006821) 87 426 499 0.053 0.800 Intermediate filament head (DNA binding) region Vfa1 (PF08432, IPR013640) 181 427 571 0.00085 5.800 AAA-ATPase Vps4-associated protein 1 RNA_pol_Rpc4 (PF05132, IPR007811) 148 833 917 0.00063 6.400 RNA polymerase III RPC4 HPS3_Mid (PF14762, IPR028167) 389 866 942 0.00085 4.200 Hermansky-Pudlak syndrome 3, middle region SR-25 (PF10500, IPR019532) 227 978 1081 0.0068 2.100 Nuclear RNA-splicing-associated protein zf-CXXC (PF02008, IPR002857) 48 1147 1194 3.2e-17 48.700 CXXC zinc finger domain Actin (PF00022, IPR004000, SM00268) 407 1169 1269 0.00028 5.600 Actin PHD (PF00628, IPR019787, SM00249) 52 1433 1482 8.9e-08 18.300 PHD-finger Bromodomain (PF00439, IPR001487, SM00297) 84 1692 1754 1.1e-06 15.000 Bromodomain zf-HC5HC2H (PF13771) 90 1903 1981 3.3e-14 39.200 PHD-like zinc-binding domain FYRN (PF05964, IPR003888, SM00541) 51 2027 2074 8.7e-20 56.700 F/Y-rich N-terminus DUF1777 (PF08648, IPR013957) 171 2364 2546 0.022 1.200 Protein of unknown function (DUF1777) YL1 (PF05764, IPR008895) 242 3302 3410 0.04 0.100 YL1 nuclear protein AF-4 (PF05110, IPR007797) 1227 4565 5456 0 1110.100 AF-4 proto-oncoprotein Updated: 2019-02-02 Owner: ChiTaRS	KMT2A A0A3B3ISN4 A0A3B3ITT0 A0A3B3ITT7 A0A3B3ITZ6 A0A3S6YZ73 A0A4D6WIU0 A0A4D6WLI1 A0A4D6WN96 A0A4D6WQ80 E9PR05 H0YEU4 H7C5V8 H7C5W4 L0R899 Q03164 Q9HBJ4 Q9UBJ5 Q9UM91 Q9UPD0 Q9Y6P1 XM_011542829.2	2..4345 99.9%	+ 11	AFF1 D6RAU0 D6RIZ5 E7EMC5 E7ETI4 F5GXF9 H0Y9S4 P51825 Q05D98 Q14C88 Q712L1 XM_005263007.3	4338..6940 99.9%	+ 4	0 10617 45499	exon-exon		BREAKPOINTs more info 1423625 1991161 3496135 7579356 7579356 7689231 7689231 7748964 7794749 7827204 8161794 8162575 8180386 8219184 8358709 8378328 8414518 8443374 8506309 8703835 9250788 9680349 9731046 9731046 10416593 10773450 11167741 11420702 11493704 11886378 11930009 11930009 11943339 12750700 12791662 12885467 12972812 15650057 15650057 15650057 16123216 16123216 16424875 16511515 17039234 17039237 17287854 17407135 17410185 17410185 17410185 17889710 19141862 19144982 19459927 20016535 20107154 21354057 21935650 23349309 23628958 24415536 26410102 27265895 27428428 28790105 28790105
3 Homo Sapiens	SplGraphs AF024541 ANNOTATION OF CHIMERA FUSION GenBank ID: AF024541 FASTA Head Gene (1) Alignment: KMT2A | OMIM: 159555 Tail Gene (2) Alignment: AFF1 | OMIM: 159557 Qsize UCSC Version Location: exons highlight1 Location: exons highlight2 Entrez GeneID1 chromo- some1 strand1 start_loc1 end_loc1 total1 overlap1 Entrez GeneID2 chromo- some2 strand2 start_loc2 end_loc2 total2 overlap2 18 19 7 20 21 22 23 - 24 25 12 26 27 28 29 - 30 31 4297 11 + 118482434 118482495 9 1 oncogene 4299 4 + 87084118 87108274 17 1 oncogene 495 hg38 Domains of the full fusion Envelope E-value Score Description name (Pfam, InterPro, SMART) length from to Filament_head (PF04732, IPR006821) 87 53 131 0.0088 3.300 Intermediate filament head (DNA binding) region YL1 (PF05764, IPR008895) 242 80 229 0.014 1.700 YL1 nuclear protein AT_hook (PF02178, IPR017956, SM00384) 13 219 227 0.0014 5.200 AT hook motif Ribosomal_60s (PF00428, IPR001813) 88 366 420 0.008 3.100 60s Acidic ribosomal protein Vfa1 (PF08432, IPR013640) 181 429 571 0.00032 7.200 AAA-ATPase Vps4-associated protein 1 DUF3915 (PF13054, IPR025026) 123 856 909 0.00011 8.400 Protein of unknown function (DUF3915) SR-25 (PF10500, IPR019532) 227 979 1082 0.0025 3.500 Nuclear RNA-splicing-associated protein Stm1_N (PF09598, IPR019084) 65 1107 1159 0.026 1.800 Stm1 zf-CXXC (PF02008, IPR002857) 48 1147 1194 1.2e-17 50.000 CXXC zinc finger domain DUF755 (PF05501, IPR008474) 123 1170 1262 0.017 1.700 Domain of unknown function (DUF755) AF-4 (PF05110, IPR007797) 1227 1351 2224 0 1139.300 AF-4 proto-oncoprotein Updated: 2019-02-02 Owner: ChiTaRS	KMT2A A0A3B3ISN4 A0A3B3ITT0 A0A3B3ITT7 A0A3B3ITZ6 A0A3S6YZ73 A0A4D6WIU0 A0A4D6WLI1 A0A4D6WN96 A0A4D6WQ80 E9PR05 H0YEU4 H7C5V8 H7C5W4 L0R899 Q03164 Q9HBJ4 Q9UBJ5 Q9UM91 Q9UPD0 Q9Y6P1 XM_011542829.2	1..62 100.0%	+ 11	AFF1 D6RAU0 D6RIZ5 E7EMC5 E7ETI4 F5GXF9 H0Y9S4 P51825 Q05D98 Q14C88 Q712L1 XM_005263007.3	61..495 100.0%	+ 4	61 0 0	exon-exon		BREAKPOINTs more info 1423625 1991161 3496135 7579356 7579356 7689231 7689231 7748964 7794749 7827204 8161794 8162575 8180386 8219184 8358709 8378328 8414518 8443374 8506309 8703835 9250788 9680349 9731046 9731046 10416593 10773450 11167741 11420702 11493704 11886378 11930009 11930009 11943339 12750700 12791662 12885467 12972812 15650057 15650057 15650057 16123216 16123216 16424875 16511515 17039234 17039237 17287854 17407135 17410185 17410185 17410185 17889710 19141862 19144982 19459927 20016535 20107154 21354057 21935650 23349309 23628958 24415536 26410102 27265895 27428428 28790105 28790105
4 Homo Sapiens	SplGraphs AF031404 ANNOTATION OF CHIMERA FUSION GenBank ID: AF031404 FASTA Head Gene (1) Alignment: KMT2A | OMIM: 159555 Tail Gene (2) Alignment: AFF1 | OMIM: 159557 Qsize UCSC Version Location: exons highlight1 Location: exons highlight2 Entrez GeneID1 chromo- some1 strand1 start_loc1 end_loc1 total1 overlap1 Entrez GeneID2 chromo- some2 strand2 start_loc2 end_loc2 total2 overlap2 18 19 7 20 21 22 23 - 24 25 12 26 27 28 29 - 30 31 4297 11 + 118482434 118484975 11 1 oncogene 4299 4 + 87084118 87108274 17 1 oncogene 741 hg38 Domains of the full fusion Envelope E-value Score Description name (Pfam, InterPro, SMART) length from to Filament_head (PF04732, IPR006821) 87 53 131 0.0091 3.200 Intermediate filament head (DNA binding) region YL1 (PF05764, IPR008895) 242 80 229 0.014 1.600 YL1 nuclear protein AT_hook (PF02178, IPR017956, SM00384) 13 219 227 0.0015 5.100 AT hook motif Ribosomal_60s (PF00428, IPR001813) 88 366 420 0.0084 3.000 60s Acidic ribosomal protein Vfa1 (PF08432, IPR013640) 181 429 571 0.00033 7.200 AAA-ATPase Vps4-associated protein 1 DUF3915 (PF13054, IPR025026) 123 856 909 0.00012 8.400 Protein of unknown function (DUF3915) SR-25 (PF10500, IPR019532) 227 979 1081 0.0026 3.500 Nuclear RNA-splicing-associated protein Stm1_N (PF09598, IPR019084) 65 1107 1159 0.027 1.700 Stm1 zf-CXXC (PF02008, IPR002857) 48 1147 1194 1.3e-17 50.000 CXXC zinc finger domain DUF755 (PF05501, IPR008474) 123 1170 1262 0.017 1.600 Domain of unknown function (DUF755) AF-4 (PF05110, IPR007797) 1227 1434 2306 0 1146.500 AF-4 proto-oncoprotein Updated: 2019-02-02 Owner: ChiTaRS	KMT2A A0A3B3ISN4 A0A3B3ITT0 A0A3B3ITT7 A0A3B3ITZ6 A0A3S6YZ73 A0A4D6WIU0 A0A4D6WLI1 A0A4D6WN96 A0A4D6WQ80 E9PR05 H0YEU4 H7C5V8 H7C5W4 L0R899 Q03164 Q9HBJ4 Q9UBJ5 Q9UM91 Q9UPD0 Q9Y6P1 XM_011542829.2	1..308 99.7%	+ 11	AFF1 D6RAU0 D6RIZ5 E7EMC5 E7ETI4 F5GXF9 H0Y9S4 P51825 Q05D98 Q14C88 Q712L1 XM_005263007.3	307..741 100.0%	+ 4	61 0 0	exon-exon		BREAKPOINTs more info 1423625 1991161 3496135 7579356 7579356 7689231 7689231 7748964 7794749 7827204 8161794 8162575 8180386 8219184 8358709 8378328 8414518 8443374 8506309 8703835 9250788 9680349 9731046 9731046 10416593 10773450 11167741 11420702 11493704 11886378 11930009 11930009 11943339 12750700 12791662 12885467 12972812 15650057 15650057 15650057 16123216 16123216 16424875 16511515 17039234 17039237 17287854 17407135 17410185 17410185 17410185 17889710 19141862 19144982 19459927 20016535 20107154 21354057 21935650 23349309 23628958 24415536 26410102 27265895 27428428 28790105 28790105
5 Homo Sapiens	SplGraphs AF177237 ANNOTATION OF CHIMERA FUSION GenBank ID: AF177237 FASTA Head Gene (1) Alignment: KMT2A | OMIM: 159555 Tail Gene (2) Alignment: AFF1 | OMIM: 159557 Qsize UCSC Version Location: exons highlight1 Location: exons highlight2 Entrez GeneID1 chromo- some1 strand1 start_loc1 end_loc1 total1 overlap1 Entrez GeneID2 chromo- some2 strand2 start_loc2 end_loc2 total2 overlap2 18 19 7 20 21 22 23 - 24 25 12 26 27 28 29 - 30 31 4297 11 + 118482434 118482496 9 1 oncogene 4299 4 + 87089982 87108274 16 1 oncogene 450 hg38 Domains of the full fusion Envelope E-value Score Description name (Pfam, InterPro, SMART) length from to Filament_head (PF04732, IPR006821) 87 53 131 0.0087 3.300 Intermediate filament head (DNA binding) region YL1 (PF05764, IPR008895) 242 80 229 0.014 1.700 YL1 nuclear protein AT_hook (PF02178, IPR017956, SM00384) 13 219 227 0.0014 5.200 AT hook motif Ribosomal_60s (PF00428, IPR001813) 88 366 420 0.008 3.100 60s Acidic ribosomal protein Vfa1 (PF08432, IPR013640) 181 429 571 0.00032 7.200 AAA-ATPase Vps4-associated protein 1 DUF3915 (PF13054, IPR025026) 123 856 909 0.00011 8.400 Protein of unknown function (DUF3915) SR-25 (PF10500, IPR019532) 227 979 1082 0.0025 3.600 Nuclear RNA-splicing-associated protein Stm1_N (PF09598, IPR019084) 65 1107 1159 0.026 1.800 Stm1 zf-CXXC (PF02008, IPR002857) 48 1147 1194 1.2e-17 50.000 CXXC zinc finger domain DUF755 (PF05501, IPR008474) 123 1170 1262 0.016 1.700 Domain of unknown function (DUF755) AF-4 (PF05110, IPR007797) 1227 1361 2209 0 1105.700 AF-4 proto-oncoprotein Updated: 2019-02-02 Owner: ChiTaRS	KMT2A A0A3B3ISN4 A0A3B3ITT0 A0A3B3ITT7 A0A3B3ITZ6 A0A3S6YZ73 A0A4D6WIU0 A0A4D6WLI1 A0A4D6WN96 A0A4D6WQ80 E9PR05 H0YEU4 H7C5V8 H7C5W4 L0R899 Q03164 Q9HBJ4 Q9UBJ5 Q9UM91 Q9UPD0 Q9Y6P1 XM_011542829.2	1..63 100.0%	+ 11	AFF1 D6RAU0 D6RIZ5 E7EMC5 E7ETI4 F5GXF9 H0Y9S4 P51825 Q05D98 Q14C88 Q712L1 XM_005263007.3	61..450 100.0%	+ 4	61 0 0	exon-exon		BREAKPOINTs more info 1423625 1991161 3496135 7579356 7579356 7689231 7689231 7748964 7794749 7827204 8161794 8162575 8180386 8219184 8358709 8378328 8414518 8443374 8506309 8703835 9250788 9680349 9731046 9731046 10416593 10773450 11167741 11420702 11493704 11886378 11930009 11930009 11943339 12750700 12791662 12885467 12972812 15650057 15650057 15650057 16123216 16123216 16424875 16511515 17039234 17039237 17287854 17407135 17410185 17410185 17410185 17889710 19141862 19144982 19459927 20016535 20107154 21354057 21935650 23349309 23628958 24415536 26410102 27265895 27428428 28790105 28790105
6 Homo Sapiens	ChimerDB AF487905 ANNOTATION OF CHIMERA FUSION GenBank ID: AF487905 FASTA UniProtKB: Q8TD98 MLL/AF4 fusion protein (Fragment) Head Gene (1) Alignment: KMT2A | OMIM: 159555 Tail Gene (2) Alignment: AFF1 | OMIM: 159557 Qsize UCSC Version Location: exons highlight1 Location: exons highlight2 Entrez GeneID1 chromo- some1 strand1 start_loc1 end_loc1 total1 overlap1 Entrez GeneID2 chromo- some2 strand2 start_loc2 end_loc2 total2 overlap2 18 19 7 20 21 22 23 - 24 25 12 26 27 28 29 - 30 31 4297 11 + 118482009 118484975 11 1 oncogene 4299 4 + 87084118 87125084 17 1 oncogene 1874 hg38 Domains of the full fusion Envelope E-value Score Description name (Pfam, InterPro, SMART) length from to Secretin_N_2 (PF07655, IPR011514) 95 61 109 0.024 1.500 Secretin N-terminal domain YL1 (PF05764, IPR008895) 242 80 229 0.016 1.400 YL1 nuclear protein AT_hook (PF02178, IPR017956, SM00384) 13 219 227 0.0016 5.000 AT hook motif Ribosomal_60s (PF00428, IPR001813) 88 366 420 0.0093 2.900 60s Acidic ribosomal protein Vfa1 (PF08432, IPR013640) 181 429 571 0.00037 7.000 AAA-ATPase Vps4-associated protein 1 DUF3915 (PF13054, IPR025026) 123 856 909 0.00013 8.200 Protein of unknown function (DUF3915) SR-25 (PF10500, IPR019532) 227 978 1082 0.0027 3.400 Nuclear RNA-splicing-associated protein zf-CXXC (PF02008, IPR002857) 48 1147 1194 1.4e-17 49.800 CXXC zinc finger domain DUF755 (PF05501, IPR008474) 123 1170 1262 0.019 1.500 Domain of unknown function (DUF755) AF-4 (PF05110, IPR007797) 1227 1434 1988 2.6e-143 465.600 AF-4 proto-oncoprotein Updated: 2019-02-20 Owner: ChiTaRS	KMT2A A0A3B3ISN4 A0A3B3ITT0 A0A3B3ITT7 A0A3B3ITZ6 A0A3S6YZ73 A0A4D6WIU0 A0A4D6WLI1 A0A4D6WN96 A0A4D6WQ80 E9PR05 H0YEU4 H7C5V8 H7C5W4 L0R899 Q03164 Q9HBJ4 Q9UBJ5 Q9UM91 Q9UPD0 Q9Y6P1 XM_011542829.2	1..404 100.0%	+ 11	AFF1 D6RAU0 D6RIZ5 E7EMC5 E7ETI4 F5GXF9 H0Y9S4 P51825 Q05D98 Q14C88 Q712L1 XM_005263007.3	403..1874 99.7%	+ 4	0 10606 13	exon-exon		BREAKPOINTs more info 1423625 1991161 3496135 7579356 7579356 7689231 7689231 7748964 7794749 7827204 8161794 8162575 8180386 8219184 8358709 8378328 8414518 8443374 8506309 8703835 9250788 9680349 9731046 9731046 10416593 10773450 11167741 11420702 11493704 11886378 11930009 11930009 11943339 12750700 12791662 12885467 12972812 15650057 15650057 15650057 16123216 16123216 16424875 16511515 17039234 17039237 17287854 17407135 17410185 17410185 17410185 17889710 19141862 19144982 19459927 20016535 20107154 21354057 21935650 23349309 23628958 24415536 26410102 27265895 27428428 28790105 28790105
7 Homo Sapiens	ChimerDB AF487906 ANNOTATION OF CHIMERA FUSION GenBank ID: AF487906 FASTA UniProtKB: Q8TD97 AF4/MLL fusion protein (Fragment) Head Gene (1) Alignment: AFF1 | OMIM: 159557 Tail Gene (2) Alignment: KMT2A | OMIM: 159555 Qsize UCSC Version Location: exons highlight1 Location: exons highlight2 Entrez GeneID1 chromo- some1 strand1 start_loc1 end_loc1 total1 overlap1 Entrez GeneID2 chromo- some2 strand2 start_loc2 end_loc2 total2 overlap2 18 19 7 20 21 22 23 - 24 25 12 26 27 28 29 - 30 31 4299 4 + 87047391 87047600 4 1 oncogene 4297 11 + 118488612 118489875 26 1 oncogene 435 hg38 Domains of the full fusion Envelope E-value Score Description name (Pfam, InterPro, SMART) length from to AF-4 (PF05110, IPR007797) 1227 15 367 3.7e-130 422.100 AF-4 proto-oncoprotein PHD (PF00628, IPR019787, SM00249) 52 346 391 8.9e-08 18.300 PHD-finger DZR (PF12773, IPR025874) 49 435 482 0.014 1.700 Double zinc ribbon Bromodomain (PF00439, IPR001487, SM00297) 84 601 663 5.5e-07 15.900 Bromodomain zf-HC5HC2H (PF13771) 90 812 890 1.6e-14 40.200 PHD-like zinc-binding domain FYRN (PF05964, IPR003888, SM00541) 51 936 983 4.4e-20 57.700 F/Y-rich N-terminus FYRC (PF05965, IPR003889, SM00542) 83 2578 2660 1.1e-25 76.000 F/Y rich C-terminus SET (PF00856, IPR001214, SM00317) 169 2752 2857 6.7e-26 77.800 SET domain Updated: 2019-02-20 Owner: ChiTaRS	AFF1 D6RAU0 D6RIZ5 E7EMC5 E7ETI4 F5GXF9 H0Y9S4 P51825 Q05D98 Q14C88 Q712L1 XM_005263007.3	1..211 98.6%	+ 4	KMT2A A0A3B3ISN4 A0A3B3ITT0 A0A3B3ITT7 A0A3B3ITZ6 A0A3S6YZ73 A0A4D6WIU0 A0A4D6WLI1 A0A4D6WN96 A0A4D6WQ80 E9PR05 H0YEU4 H7C5V8 H7C5W4 L0R899 Q03164 Q9HBJ4 Q9UBJ5 Q9UM91 Q9UPD0 Q9Y6P1 XM_011542829.2	203..435 99.6%	+ 11	61 0 0	exon-exon		BREAKPOINTs more info 1423625 1991161 3496135 7579356 7579356 7689231 7689231 7748964 7794749 7827204 8161794 8162575 8180386 8219184 8358709 8378328 8414518 8443374 8506309 8703835 9250788 9680349 9731046 9731046 10416593 10773450 11167741 11420702 11493704 11886378 11930009 11930009 11943339 12750700 12791662 12885467 12972812 15650057 15650057 15650057 16123216 16123216 16424875 16511515 17039234 17039237 17287854 17407135 17410185 17410185 17410185 17889710 19141862 19144982 19459927 20016535 20107154 21354057 21935650 23349309 23628958 24415536 26410102 27265895 27428428 28790105 28790105
8 Homo Sapiens	ChimerDB AF492831 ANNOTATION OF CHIMERA FUSION GenBank ID: AF492831 FASTA UniProtKB: Q8NI10 AF4/MLL fusion protein (Fragment) Head Gene (1) Alignment: AFF1 | OMIM: 159557 Tail Gene (2) Alignment: KMT2A | OMIM: 159555 Qsize UCSC Version Location: exons highlight1 Location: exons highlight2 Entrez GeneID1 chromo- some1 strand1 start_loc1 end_loc1 total1 overlap1 Entrez GeneID2 chromo- some2 strand2 start_loc2 end_loc2 total2 overlap2 18 19 7 20 21 22 23 - 24 25 12 26 27 28 29 - 30 31 4299 4 + 87047391 87047600 4 1 oncogene 4297 11 + 118488612 118488702 26 1 oncogene 293 hg38 Domains of the full fusion Envelope E-value Score Description name (Pfam, InterPro, SMART) length from to AF-4 (PF05110, IPR007797) 1227 15 367 3.7e-130 422.100 AF-4 proto-oncoprotein PHD (PF00628, IPR019787, SM00249) 52 346 391 8.9e-08 18.300 PHD-finger DZR (PF12773, IPR025874) 49 435 482 0.014 1.700 Double zinc ribbon Bromodomain (PF00439, IPR001487, SM00297) 84 601 663 5.5e-07 15.900 Bromodomain zf-HC5HC2H (PF13771) 90 812 890 1.6e-14 40.200 PHD-like zinc-binding domain FYRN (PF05964, IPR003888, SM00541) 51 936 983 4.4e-20 57.700 F/Y-rich N-terminus FYRC (PF05965, IPR003889, SM00542) 83 2578 2660 1.1e-25 76.000 F/Y rich C-terminus SET (PF00856, IPR001214, SM00317) 169 2752 2857 6.7e-26 77.800 SET domain Updated: 2019-02-20 Owner: ChiTaRS	AFF1 D6RAU0 D6RIZ5 E7EMC5 E7ETI4 F5GXF9 H0Y9S4 P51825 Q05D98 Q14C88 Q712L1 XM_005263007.3	1..211 98.6%	+ 4	KMT2A A0A3B3ISN4 A0A3B3ITT0 A0A3B3ITT7 A0A3B3ITZ6 A0A3S6YZ73 A0A4D6WIU0 A0A4D6WLI1 A0A4D6WN96 A0A4D6WQ80 E9PR05 H0YEU4 H7C5V8 H7C5W4 L0R899 Q03164 Q9HBJ4 Q9UBJ5 Q9UM91 Q9UPD0 Q9Y6P1 XM_011542829.2	203..293 100.0%	+ 11	61 0 0	exon-exon		BREAKPOINTs more info 1423625 1991161 3496135 7579356 7579356 7689231 7689231 7748964 7794749 7827204 8161794 8162575 8180386 8219184 8358709 8378328 8414518 8443374 8506309 8703835 9250788 9680349 9731046 9731046 10416593 10773450 11167741 11420702 11493704 11886378 11930009 11930009 11943339 12750700 12791662 12885467 12972812 15650057 15650057 15650057 16123216 16123216 16424875 16511515 17039234 17039237 17287854 17407135 17410185 17410185 17410185 17889710 19141862 19144982 19459927 20016535 20107154 21354057 21935650 23349309 23628958 24415536 26410102 27265895 27428428 28790105 28790105
9 Homo Sapiens	ChimerDB AF492832 ANNOTATION OF CHIMERA FUSION GenBank ID: AF492832 FASTA UniProtKB: Q8NI09 MLL/AF4 fusion protein (Fragment) Head Gene (1) Alignment: KMT2A | OMIM: 159555 Tail Gene (2) Alignment: AFF1 | OMIM: 159557 Qsize UCSC Version Location: exons highlight1 Location: exons highlight2 Entrez GeneID1 chromo- some1 strand1 start_loc1 end_loc1 total1 overlap1 Entrez GeneID2 chromo- some2 strand2 start_loc2 end_loc2 total2 overlap2 18 19 7 20 21 22 23 - 24 25 12 26 27 28 29 - 30 31 4297 11 + 118482434 118484975 11 1 oncogene 4299 4 + 87084118 87108274 17 1 oncogene 741 hg38 Domains of the full fusion Envelope E-value Score Description name (Pfam, InterPro, SMART) length from to Filament_head (PF04732, IPR006821) 87 53 131 0.0091 3.200 Intermediate filament head (DNA binding) region YL1 (PF05764, IPR008895) 242 80 229 0.014 1.600 YL1 nuclear protein AT_hook (PF02178, IPR017956, SM00384) 13 219 227 0.0015 5.100 AT hook motif Ribosomal_60s (PF00428, IPR001813) 88 366 420 0.0084 3.000 60s Acidic ribosomal protein Vfa1 (PF08432, IPR013640) 181 429 571 0.00033 7.200 AAA-ATPase Vps4-associated protein 1 DUF3915 (PF13054, IPR025026) 123 856 909 0.00012 8.400 Protein of unknown function (DUF3915) SR-25 (PF10500, IPR019532) 227 979 1081 0.0026 3.500 Nuclear RNA-splicing-associated protein Stm1_N (PF09598, IPR019084) 65 1107 1159 0.027 1.700 Stm1 zf-CXXC (PF02008, IPR002857) 48 1147 1194 1.3e-17 50.000 CXXC zinc finger domain DUF755 (PF05501, IPR008474) 123 1170 1262 0.017 1.600 Domain of unknown function (DUF755) AF-4 (PF05110, IPR007797) 1227 1434 2306 0 1146.500 AF-4 proto-oncoprotein Updated: 2019-02-20 Owner: ChiTaRS	KMT2A A0A3B3ISN4 A0A3B3ITT0 A0A3B3ITT7 A0A3B3ITZ6 A0A3S6YZ73 A0A4D6WIU0 A0A4D6WLI1 A0A4D6WN96 A0A4D6WQ80 E9PR05 H0YEU4 H7C5V8 H7C5W4 L0R899 Q03164 Q9HBJ4 Q9UBJ5 Q9UM91 Q9UPD0 Q9Y6P1 XM_011542829.2	1..308 100.0%	+ 11	AFF1 D6RAU0 D6RIZ5 E7EMC5 E7ETI4 F5GXF9 H0Y9S4 P51825 Q05D98 Q14C88 Q712L1 XM_005263007.3	307..741 100.0%	+ 4	61 0 0	exon-exon		BREAKPOINTs more info 1423625 1991161 3496135 7579356 7579356 7689231 7689231 7748964 7794749 7827204 8161794 8162575 8180386 8219184 8358709 8378328 8414518 8443374 8506309 8703835 9250788 9680349 9731046 9731046 10416593 10773450 11167741 11420702 11493704 11886378 11930009 11930009 11943339 12750700 12791662 12885467 12972812 15650057 15650057 15650057 16123216 16123216 16424875 16511515 17039234 17039237 17287854 17407135 17410185 17410185 17410185 17889710 19141862 19144982 19459927 20016535 20107154 21354057 21935650 23349309 23628958 24415536 26410102 27265895 27428428 28790105 28790105
10 Homo Sapiens	ChimerDB AF177239 ANNOTATION OF CHIMERA FUSION GenBank ID: AF177239 FASTA Head Gene (1) Alignment: AFF1 | OMIM: 159557 Tail Gene (2) Alignment: KMT2A | OMIM: 159555 Qsize UCSC Version Location: exons highlight1 Location: exons highlight2 Entrez GeneID1 chromo- some1 strand1 start_loc1 end_loc1 total1 overlap1 Entrez GeneID2 chromo- some2 strand2 start_loc2 end_loc2 total2 overlap2 18 19 7 20 21 22 23 - 24 25 12 26 27 28 29 - 30 31 4299 4 + 87047160 87084165 5 1 oncogene 4297 11 + 118484181 118484298 28 1 oncogene 596 hg38 Domains of the full fusion Envelope E-value Score Description name (Pfam, InterPro, SMART) length from to AF-4 (PF05110, IPR007797) 1227 15 414 5.9e-140 454.500 AF-4 proto-oncoprotein PHD (PF00628, IPR019787, SM00249) 52 439 488 4.1e-08 19.400 PHD-finger DZR (PF12773, IPR025874) 49 532 579 0.015 1.700 Double zinc ribbon Bromodomain (PF00439, IPR001487, SM00297) 84 698 760 5.7e-07 15.900 Bromodomain zf-HC5HC2H (PF13771) 90 909 987 1.7e-14 40.200 PHD-like zinc-binding domain FYRN (PF05964, IPR003888, SM00541) 51 1033 1080 4.6e-20 57.600 F/Y-rich N-terminus FYRC (PF05965, IPR003889, SM00542) 83 2675 2757 1.1e-25 75.900 F/Y rich C-terminus SET (PF00856, IPR001214, SM00317) 169 2849 2954 6.9e-26 77.800 SET domain Updated: 2019-02-20 Owner: ChiTaRS	AFF1 D6RAU0 D6RIZ5 E7EMC5 E7ETI4 F5GXF9 H0Y9S4 P51825 Q05D98 Q14C88 Q712L1 XM_005263007.3	1..481 100.0%	+ 4	KMT2A A0A3B3ISN4 A0A3B3ITT0 A0A3B3ITT7 A0A3B3ITZ6 A0A3S6YZ73 A0A4D6WIU0 A0A4D6WLI1 A0A4D6WN96 A0A4D6WQ80 E9PR05 H0YEU4 H7C5V8 H7C5W4 L0R899 Q03164 Q9HBJ4 Q9UBJ5 Q9UM91 Q9UPD0 Q9Y6P1 XM_011542829.2	479..596 100.0%	+ 11	61 0 0	exon-exon		BREAKPOINTs more info 1423625 1991161 3496135 7579356 7579356 7689231 7689231 7748964 7794749 7827204 8161794 8162575 8180386 8219184 8358709 8378328 8414518 8443374 8506309 8703835 9250788 9680349 9731046 9731046 10416593 10773450 11167741 11420702 11493704 11886378 11930009 11930009 11943339 12750700 12791662 12885467 12972812 15650057 15650057 15650057 16123216 16123216 16424875 16511515 17039234 17039237 17287854 17407135 17410185 17410185 17410185 17889710 19141862 19144982 19459927 20016535 20107154 21354057 21935650 23349309 23628958 24415536 26410102 27265895 27428428 28790105 28790105

T o p