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Rank: Junction Consistence: Hi-C Sense-ANTIsense

Mass-spec hits Read-through chimeras Breakpoints RNAseq evidence
Organisms
Homo Sapiens Mus musculus D.Melanogaster
Rattus Norvegicus Bos Taurus Danio Rerio
Saccharomyces Cerevisiae Sus ScrofaAll organisms

Result for the search: Gene Name/NCBI ID(s): '4297,4299'

Total of fusion sequences: 164 (from 1,393,046 parsed EST/mRNAs. Last update 2019-09-04)

Organism Fusion:
Graphical View,
Annotation,
PPI network 		Head Gene (1) Tail Gene (2) Rank,
Deviation:
Eloc(x)
Sloc(y) 		Fusion type RNA Hi-C,
RNAseq,
Mass-spec
evidences		 Cancer
Breakpoint,
PubMed(s)
Name(s)1,
transcript		 Start1..End1
Ident1% 		Strand1
Chrom1 		Name(s)2,
transcript		 Start2..End2
Ident2% 		Strand2
Chrom2
1234,5,67,1989,10,1112,2513,14,15-1617
Homo SapiensSplGraphs

ANNOTATION OF CHIMERA FUSION

GenBank ID: DQ451148 FASTA
UniProtKB: Q0ZHH1 MLL-AF4 fusion protein (Fragment)
Head Gene (1) Alignment: KMT2A | OMIM: 159555 Tail Gene (2) Alignment: AFF1 | OMIM: 159557 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
429711+11848204211848249691oncogene42994+8709179187094967151oncogene 215 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
Filament_head (PF04732, IPR006821) 87 53 131 0.0086 3.300 Intermediate filament head (DNA binding) region
YL1 (PF05764, IPR008895) 242 80 229 0.013 1.700 YL1 nuclear protein
AT_hook (PF02178, IPR017956, SM00384) 13 219 227 0.0014 5.200 AT hook motif
Ribosomal_60s (PF00428, IPR001813) 88 366 420 0.0079 3.100 60s Acidic ribosomal protein
Vfa1 (PF08432, IPR013640) 181 429 571 0.00031 7.300 AAA-ATPase Vps4-associated protein 1
DUF3915 (PF13054, IPR025026) 123 856 909 0.00011 8.400 Protein of unknown function (DUF3915)
SR-25 (PF10500, IPR019532) 227 979 1082 0.0024 3.600 Nuclear RNA-splicing-associated protein
Stm1_N (PF09598, IPR019084) 65 1107 1159 0.025 1.800 Stm1
zf-CXXC (PF02008, IPR002857) 48 1147 1194 1.2e-17 50.000 CXXC zinc finger domain
DUF755 (PF05501, IPR008474) 123 1170 1262 0.016 1.700 Domain of unknown function (DUF755)
AF-4 (PF05110, IPR007797) 1227 1349 2180 0 1025.500 AF-4 proto-oncoprotein
Updated: 2019-02-02
Owner: ChiTaRS
XM_011542829.2		1..126
100.0%		+
11
XM_005263007.3		124..215
100.0%		+
4		61
2
214		exon-exonBREAKPOINTs
Homo SapiensSplGraphs

ANNOTATION OF CHIMERA FUSION

GenBank ID: L22179 FASTA
Head Gene (1) Alignment: KMT2A | OMIM: 159555 Tail Gene (2) Alignment: AFF1 | OMIM: 159557 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
429711+118436510118484314101oncogene42994+8708411287135701171oncogene 6940 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
Ery_res_leader2 (PF08057, IPR012559) 14 1 12 0.0034 4.700 Erythromycin resistance leader peptide
DUF3446 (PF11928, IPR021849) 88 51 121 0.011 2.400 Domain of unknown function (DUF3446)
AT_hook (PF02178, IPR017956, SM00384) 13 219 227 0.0037 3.900 AT hook motif
Ribosomal_60s (PF00428, IPR001813) 88 367 420 0.023 1.600 60s Acidic ribosomal protein
Filament_head (PF04732, IPR006821) 87 426 499 0.053 0.800 Intermediate filament head (DNA binding) region
Vfa1 (PF08432, IPR013640) 181 427 571 0.00085 5.800 AAA-ATPase Vps4-associated protein 1
RNA_pol_Rpc4 (PF05132, IPR007811) 148 833 917 0.00063 6.400 RNA polymerase III RPC4
HPS3_Mid (PF14762, IPR028167) 389 866 942 0.00085 4.200 Hermansky-Pudlak syndrome 3, middle region
SR-25 (PF10500, IPR019532) 227 978 1081 0.0068 2.100 Nuclear RNA-splicing-associated protein
zf-CXXC (PF02008, IPR002857) 48 1147 1194 3.2e-17 48.700 CXXC zinc finger domain
Actin (PF00022, IPR004000, SM00268) 407 1169 1269 0.00028 5.600 Actin
PHD (PF00628, IPR019787, SM00249) 52 1433 1482 8.9e-08 18.300 PHD-finger
Bromodomain (PF00439, IPR001487, SM00297) 84 1692 1754 1.1e-06 15.000 Bromodomain
zf-HC5HC2H (PF13771) 90 1903 1981 3.3e-14 39.200 PHD-like zinc-binding domain
FYRN (PF05964, IPR003888, SM00541) 51 2027 2074 8.7e-20 56.700 F/Y-rich N-terminus
DUF1777 (PF08648, IPR013957) 171 2364 2546 0.022 1.200 Protein of unknown function (DUF1777)
YL1 (PF05764, IPR008895) 242 3302 3410 0.04 0.100 YL1 nuclear protein
AF-4 (PF05110, IPR007797) 1227 4565 5456 0 1110.100 AF-4 proto-oncoprotein
Updated: 2019-02-02
Owner: ChiTaRS
XM_011542829.2		2..4345
99.9%		+
11
XM_005263007.3		4338..6940
99.9%		+
4		0
10617
45499		exon-exonBREAKPOINTs
Homo SapiensSplGraphs

ANNOTATION OF CHIMERA FUSION

GenBank ID: AF024541 FASTA
Head Gene (1) Alignment: KMT2A | OMIM: 159555 Tail Gene (2) Alignment: AFF1 | OMIM: 159557 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
429711+11848243411848249591oncogene42994+8708411887108274171oncogene 495 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
Filament_head (PF04732, IPR006821) 87 53 131 0.0088 3.300 Intermediate filament head (DNA binding) region
YL1 (PF05764, IPR008895) 242 80 229 0.014 1.700 YL1 nuclear protein
AT_hook (PF02178, IPR017956, SM00384) 13 219 227 0.0014 5.200 AT hook motif
Ribosomal_60s (PF00428, IPR001813) 88 366 420 0.008 3.100 60s Acidic ribosomal protein
Vfa1 (PF08432, IPR013640) 181 429 571 0.00032 7.200 AAA-ATPase Vps4-associated protein 1
DUF3915 (PF13054, IPR025026) 123 856 909 0.00011 8.400 Protein of unknown function (DUF3915)
SR-25 (PF10500, IPR019532) 227 979 1082 0.0025 3.500 Nuclear RNA-splicing-associated protein
Stm1_N (PF09598, IPR019084) 65 1107 1159 0.026 1.800 Stm1
zf-CXXC (PF02008, IPR002857) 48 1147 1194 1.2e-17 50.000 CXXC zinc finger domain
DUF755 (PF05501, IPR008474) 123 1170 1262 0.017 1.700 Domain of unknown function (DUF755)
AF-4 (PF05110, IPR007797) 1227 1351 2224 0 1139.300 AF-4 proto-oncoprotein
Updated: 2019-02-02
Owner: ChiTaRS
XM_011542829.2		1..62
100.0%		+
11
XM_005263007.3		61..495
100.0%		+
4		61
0
0		exon-exonBREAKPOINTs
Homo SapiensSplGraphs

ANNOTATION OF CHIMERA FUSION

GenBank ID: AF031404 FASTA
Head Gene (1) Alignment: KMT2A | OMIM: 159555 Tail Gene (2) Alignment: AFF1 | OMIM: 159557 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
429711+118482434118484975111oncogene42994+8708411887108274171oncogene 741 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
Filament_head (PF04732, IPR006821) 87 53 131 0.0091 3.200 Intermediate filament head (DNA binding) region
YL1 (PF05764, IPR008895) 242 80 229 0.014 1.600 YL1 nuclear protein
AT_hook (PF02178, IPR017956, SM00384) 13 219 227 0.0015 5.100 AT hook motif
Ribosomal_60s (PF00428, IPR001813) 88 366 420 0.0084 3.000 60s Acidic ribosomal protein
Vfa1 (PF08432, IPR013640) 181 429 571 0.00033 7.200 AAA-ATPase Vps4-associated protein 1
DUF3915 (PF13054, IPR025026) 123 856 909 0.00012 8.400 Protein of unknown function (DUF3915)
SR-25 (PF10500, IPR019532) 227 979 1081 0.0026 3.500 Nuclear RNA-splicing-associated protein
Stm1_N (PF09598, IPR019084) 65 1107 1159 0.027 1.700 Stm1
zf-CXXC (PF02008, IPR002857) 48 1147 1194 1.3e-17 50.000 CXXC zinc finger domain
DUF755 (PF05501, IPR008474) 123 1170 1262 0.017 1.600 Domain of unknown function (DUF755)
AF-4 (PF05110, IPR007797) 1227 1434 2306 0 1146.500 AF-4 proto-oncoprotein
Updated: 2019-02-02
Owner: ChiTaRS
XM_011542829.2		1..308
99.7%		+
11
XM_005263007.3		307..741
100.0%		+
4		61
0
0		exon-exonBREAKPOINTs
Homo SapiensSplGraphs

ANNOTATION OF CHIMERA FUSION

GenBank ID: AF177237 FASTA
Head Gene (1) Alignment: KMT2A | OMIM: 159555 Tail Gene (2) Alignment: AFF1 | OMIM: 159557 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
429711+11848243411848249691oncogene42994+8708998287108274161oncogene 450 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
Filament_head (PF04732, IPR006821) 87 53 131 0.0087 3.300 Intermediate filament head (DNA binding) region
YL1 (PF05764, IPR008895) 242 80 229 0.014 1.700 YL1 nuclear protein
AT_hook (PF02178, IPR017956, SM00384) 13 219 227 0.0014 5.200 AT hook motif
Ribosomal_60s (PF00428, IPR001813) 88 366 420 0.008 3.100 60s Acidic ribosomal protein
Vfa1 (PF08432, IPR013640) 181 429 571 0.00032 7.200 AAA-ATPase Vps4-associated protein 1
DUF3915 (PF13054, IPR025026) 123 856 909 0.00011 8.400 Protein of unknown function (DUF3915)
SR-25 (PF10500, IPR019532) 227 979 1082 0.0025 3.600 Nuclear RNA-splicing-associated protein
Stm1_N (PF09598, IPR019084) 65 1107 1159 0.026 1.800 Stm1
zf-CXXC (PF02008, IPR002857) 48 1147 1194 1.2e-17 50.000 CXXC zinc finger domain
DUF755 (PF05501, IPR008474) 123 1170 1262 0.016 1.700 Domain of unknown function (DUF755)
AF-4 (PF05110, IPR007797) 1227 1361 2209 0 1105.700 AF-4 proto-oncoprotein
Updated: 2019-02-02
Owner: ChiTaRS
XM_011542829.2		1..63
100.0%		+
11
XM_005263007.3		61..450
100.0%		+
4		61
0
0		exon-exonBREAKPOINTs
Homo Sapiens ChimerDB

ANNOTATION OF CHIMERA FUSION

GenBank ID: AF487905 FASTA
UniProtKB: Q8TD98 MLL/AF4 fusion protein (Fragment)
Head Gene (1) Alignment: KMT2A | OMIM: 159555 Tail Gene (2) Alignment: AFF1 | OMIM: 159557 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
429711+118482009118484975111oncogene42994+8708411887125084171oncogene 1874 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
Secretin_N_2 (PF07655, IPR011514) 95 61 109 0.024 1.500 Secretin N-terminal domain
YL1 (PF05764, IPR008895) 242 80 229 0.016 1.400 YL1 nuclear protein
AT_hook (PF02178, IPR017956, SM00384) 13 219 227 0.0016 5.000 AT hook motif
Ribosomal_60s (PF00428, IPR001813) 88 366 420 0.0093 2.900 60s Acidic ribosomal protein
Vfa1 (PF08432, IPR013640) 181 429 571 0.00037 7.000 AAA-ATPase Vps4-associated protein 1
DUF3915 (PF13054, IPR025026) 123 856 909 0.00013 8.200 Protein of unknown function (DUF3915)
SR-25 (PF10500, IPR019532) 227 978 1082 0.0027 3.400 Nuclear RNA-splicing-associated protein
zf-CXXC (PF02008, IPR002857) 48 1147 1194 1.4e-17 49.800 CXXC zinc finger domain
DUF755 (PF05501, IPR008474) 123 1170 1262 0.019 1.500 Domain of unknown function (DUF755)
AF-4 (PF05110, IPR007797) 1227 1434 1988 2.6e-143 465.600 AF-4 proto-oncoprotein
Updated: 2019-02-20
Owner: ChiTaRS
XM_011542829.2		1..404
100.0%		+
11
XM_005263007.3		403..1874
99.7%		+
4		0
10606
13		exon-exonBREAKPOINTs
Homo Sapiens ChimerDB

ANNOTATION OF CHIMERA FUSION

GenBank ID: AF487906 FASTA
UniProtKB: Q8TD97 AF4/MLL fusion protein (Fragment)
Head Gene (1) Alignment: AFF1 | OMIM: 159557 Tail Gene (2) Alignment: KMT2A | OMIM: 159555 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
42994+870473918704760041oncogene429711+118488612118489875261oncogene 435 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
AF-4 (PF05110, IPR007797) 1227 15 367 3.7e-130 422.100 AF-4 proto-oncoprotein
PHD (PF00628, IPR019787, SM00249) 52 346 391 8.9e-08 18.300 PHD-finger
DZR (PF12773, IPR025874) 49 435 482 0.014 1.700 Double zinc ribbon
Bromodomain (PF00439, IPR001487, SM00297) 84 601 663 5.5e-07 15.900 Bromodomain
zf-HC5HC2H (PF13771) 90 812 890 1.6e-14 40.200 PHD-like zinc-binding domain
FYRN (PF05964, IPR003888, SM00541) 51 936 983 4.4e-20 57.700 F/Y-rich N-terminus
FYRC (PF05965, IPR003889, SM00542) 83 2578 2660 1.1e-25 76.000 F/Y rich C-terminus
SET (PF00856, IPR001214, SM00317) 169 2752 2857 6.7e-26 77.800 SET domain
Updated: 2019-02-20
Owner: ChiTaRS
XM_005263007.3		1..211
98.6%		+
4
XM_011542829.2		203..435
99.6%		+
11		61
0
0		exon-exonBREAKPOINTs
Homo Sapiens ChimerDB

ANNOTATION OF CHIMERA FUSION

GenBank ID: AF492831 FASTA
UniProtKB: Q8NI10 AF4/MLL fusion protein (Fragment)
Head Gene (1) Alignment: AFF1 | OMIM: 159557 Tail Gene (2) Alignment: KMT2A | OMIM: 159555 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
42994+870473918704760041oncogene429711+118488612118488702261oncogene 293 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
AF-4 (PF05110, IPR007797) 1227 15 367 3.7e-130 422.100 AF-4 proto-oncoprotein
PHD (PF00628, IPR019787, SM00249) 52 346 391 8.9e-08 18.300 PHD-finger
DZR (PF12773, IPR025874) 49 435 482 0.014 1.700 Double zinc ribbon
Bromodomain (PF00439, IPR001487, SM00297) 84 601 663 5.5e-07 15.900 Bromodomain
zf-HC5HC2H (PF13771) 90 812 890 1.6e-14 40.200 PHD-like zinc-binding domain
FYRN (PF05964, IPR003888, SM00541) 51 936 983 4.4e-20 57.700 F/Y-rich N-terminus
FYRC (PF05965, IPR003889, SM00542) 83 2578 2660 1.1e-25 76.000 F/Y rich C-terminus
SET (PF00856, IPR001214, SM00317) 169 2752 2857 6.7e-26 77.800 SET domain
Updated: 2019-02-20
Owner: ChiTaRS
XM_005263007.3		1..211
98.6%		+
4
XM_011542829.2		203..293
100.0%		+
11		61
0
0		exon-exonBREAKPOINTs
Homo Sapiens ChimerDB

ANNOTATION OF CHIMERA FUSION

GenBank ID: AF492832 FASTA
UniProtKB: Q8NI09 MLL/AF4 fusion protein (Fragment)
Head Gene (1) Alignment: KMT2A | OMIM: 159555 Tail Gene (2) Alignment: AFF1 | OMIM: 159557 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
429711+118482434118484975111oncogene42994+8708411887108274171oncogene 741 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
Filament_head (PF04732, IPR006821) 87 53 131 0.0091 3.200 Intermediate filament head (DNA binding) region
YL1 (PF05764, IPR008895) 242 80 229 0.014 1.600 YL1 nuclear protein
AT_hook (PF02178, IPR017956, SM00384) 13 219 227 0.0015 5.100 AT hook motif
Ribosomal_60s (PF00428, IPR001813) 88 366 420 0.0084 3.000 60s Acidic ribosomal protein
Vfa1 (PF08432, IPR013640) 181 429 571 0.00033 7.200 AAA-ATPase Vps4-associated protein 1
DUF3915 (PF13054, IPR025026) 123 856 909 0.00012 8.400 Protein of unknown function (DUF3915)
SR-25 (PF10500, IPR019532) 227 979 1081 0.0026 3.500 Nuclear RNA-splicing-associated protein
Stm1_N (PF09598, IPR019084) 65 1107 1159 0.027 1.700 Stm1
zf-CXXC (PF02008, IPR002857) 48 1147 1194 1.3e-17 50.000 CXXC zinc finger domain
DUF755 (PF05501, IPR008474) 123 1170 1262 0.017 1.600 Domain of unknown function (DUF755)
AF-4 (PF05110, IPR007797) 1227 1434 2306 0 1146.500 AF-4 proto-oncoprotein
Updated: 2019-02-20
Owner: ChiTaRS
XM_011542829.2		1..308
100.0%		+
11
XM_005263007.3		307..741
100.0%		+
4		61
0
0		exon-exonBREAKPOINTs
Homo Sapiens ChimerDB

ANNOTATION OF CHIMERA FUSION

GenBank ID: AF177239 FASTA
Head Gene (1) Alignment: AFF1 | OMIM: 159557 Tail Gene (2) Alignment: KMT2A | OMIM: 159555 Qsize UCSC
Version
Location:
 exons highlight1 Location:
 exons highlight2
Entrez
GeneID1		 chromo-
some1		 strand1 start_loc1 end_loc1 total1 overlap1 Entrez
GeneID2		 chromo-
some2		 strand2 start_loc2 end_loc2 total2 overlap2
1819720212223-24251226272829-3031
42994+870471608708416551oncogene429711+118484181118484298281oncogene 596 hg38

Domains of the full fusion Envelope E-value Score Description
name (Pfam, InterPro, SMART) length from to
AF-4 (PF05110, IPR007797) 1227 15 414 5.9e-140 454.500 AF-4 proto-oncoprotein
PHD (PF00628, IPR019787, SM00249) 52 439 488 4.1e-08 19.400 PHD-finger
DZR (PF12773, IPR025874) 49 532 579 0.015 1.700 Double zinc ribbon
Bromodomain (PF00439, IPR001487, SM00297) 84 698 760 5.7e-07 15.900 Bromodomain
zf-HC5HC2H (PF13771) 90 909 987 1.7e-14 40.200 PHD-like zinc-binding domain
FYRN (PF05964, IPR003888, SM00541) 51 1033 1080 4.6e-20 57.600 F/Y-rich N-terminus
FYRC (PF05965, IPR003889, SM00542) 83 2675 2757 1.1e-25 75.900 F/Y rich C-terminus
SET (PF00856, IPR001214, SM00317) 169 2849 2954 6.9e-26 77.800 SET domain
Updated: 2019-02-20
Owner: ChiTaRS
XM_005263007.3		1..481
100.0%		+
4
XM_011542829.2		479..596
100.0%		+
11		61
0
0		exon-exonBREAKPOINTs

T o p