Analysis of Chromosomal Breakpoints

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Drug Therapy:

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Set a mask for the chromosome/locus combinations

Chromosome Breakpoints info

Result of search 'TPM3 & ROS1'

Total Breakpoints: 2

PubMed
reference(s) 		Type of Aberration ChiPPI
network		 UniProtKB
fusion		 Gene symbol1 Gene symbol2 RNAseq,
Mass-spec
evidence		 Cancer type &
Drug Therapy (DT)		 Description of Diseases
1 2 3456789
more info
1		 t(1;6)(q21;q22)
 M1VPF4

Drug Therapy

Cancer Type: CESC
Cancer descriptoin: Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma
Cancer target Gene target Drug therapy Evidence level Effect Link (Pubmed)
alltypes ROS1 Crizotinib PreclinicalSensitive23486013

Drug Therapy

Cancer Type: COADREAD
Cancer descriptoin: Colon Adenocarcinoma and Rectum Adenocarcinoma
Medical Subject Headings (MeSH): D015179
Diseases Database: 2975
Cancer target Gene target Drug therapy Evidence level Effect Link (Pubmed)
alltypes ROS1 Crizotinib PreclinicalSensitive23486013
COADREAD ROS1 Crizotinib 27397505

Drug Therapy

Cancer Type: LUAD
Cancer descriptoin: Lung Adenocarcinoma
Medical Subject Headings (MeSH): D000077192
Cancer target Gene target Drug therapy Evidence level Effect Link (Pubmed)
alltypes ROS1 Crizotinib PreclinicalSensitive23486013
LUAD ROS1 Crizotinib Clinical TrialsSensitive25264305
LUAD ROS1 Crizotinib 27397505

Drug Therapy

Cancer Type: OV
Cancer descriptoin: Ovarian Serous Cystadenocarcinoma
Medical Subject Headings (MeSH): D010051
Cancer target Gene target Drug therapy Evidence level Effect Link (Pubmed)
alltypes ROS1 Crizotinib PreclinicalSensitive23486013
OV ROS1 Crizotinib 27397505

Drug Therapy

Cancer Type: PAAD
Cancer descriptoin: Pancreatic Adenocarcinoma
Medical Subject Headings (MeSH): D010190
Diseases Database: 9510
Cancer target Gene target Drug therapy Evidence level Effect Link (Pubmed)
alltypes ROS1 Crizotinib PreclinicalSensitive23486013
PAAD ROS1 Crizotinib 27397505

Drug Therapy

Cancer Type: PRAD
Cancer descriptoin: Prostate Adenocarcinoma
Medical Subject Headings (MeSH): D011471
Diseases Database: 10780
Cancer target Gene target Drug therapy Evidence level Effect Link (Pubmed)
alltypes ROS1 Crizotinib PreclinicalSensitive23486013
PRAD ROS1 Crizotinib 27397505

Drug Therapy

Cancer Type: STAD
Cancer descriptoin: Stomach Adenocarcinoma
Medical Subject Headings (MeSH): D013274
Diseases Database: 12445
Cancer target Gene target Drug therapy Evidence level Effect Link (Pubmed)
alltypes ROS1 Crizotinib PreclinicalSensitive23486013
STAD ROS1 Crizotinib 27397505
 Adenocarcinoma (CA ad).
 Melanocytic neoplasm, special type (MELN spec).
22327623
ChiTaRS
2		 t(6;1)(q22;q21.2)
 M1VPF4

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