Analysis of Chromosomal Breakpoints

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Set a mask for the chromosome/locus combinations

Chromosome Breakpoints info

Result of search 'RARA & PML'

Total Breakpoints: 10

PubMed
reference(s) 		Type of Aberration ChiPPI
network		 UniProtKB
fusion		 Gene symbol1 Gene symbol2 RNAseq,
Mass-spec
evidence		 Cancer type &
Drug Therapy (DT)		 Description of Diseases
1 2 3456789
21529941
[1]Mitelman[2]
1		 ins(15;17)(q22;q21q26)

Drug Therapy

Cancer Type: LAML
Cancer descriptoin: Acute Myeloid Leukemia
Medical Subject Headings (MeSH): D015470
Diseases Database: 203
Cancer target Gene target Drug therapy Evidence level Effect Link (Pubmed)
LAML PML ATRA + arsenic trioxide FDA Approved(level 1) Sensitive 15103387
LAML RARA ATRA + arsenic trioxide FDA Approved(level 1) Sensitive 15103387
 Acute promyelocytic leukemia (FAB type M3) (APML/APL/AML M3).
20439630
[1]Mitelman[2]
2		 der(7)(q?)

Drug Therapy

Cancer Type: LAML
Cancer descriptoin: Acute Myeloid Leukemia
Medical Subject Headings (MeSH): D015470
Diseases Database: 203
Cancer target Gene target Drug therapy Evidence level Effect Link (Pubmed)
LAML PML ATRA + arsenic trioxide FDA Approved(level 1) Sensitive 15103387
LAML RARA ATRA + arsenic trioxide FDA Approved(level 1) Sensitive 15103387
 Acute myeloid leukemia, NOS (AML NOS).
20439630
[1]Mitelman[2]
3		 der(5)(?)

Drug Therapy

Cancer Type: LAML
Cancer descriptoin: Acute Myeloid Leukemia
Medical Subject Headings (MeSH): D015470
Diseases Database: 203
Cancer target Gene target Drug therapy Evidence level Effect Link (Pubmed)
LAML PML ATRA + arsenic trioxide FDA Approved(level 1) Sensitive 15103387
LAML RARA ATRA + arsenic trioxide FDA Approved(level 1) Sensitive 15103387
 Acute myeloid leukemia, NOS (AML NOS).
more info
4		 der(11)(q23)

Drug Therapy

Cancer Type: LAML
Cancer descriptoin: Acute Myeloid Leukemia
Medical Subject Headings (MeSH): D015470
Diseases Database: 203
Cancer target Gene target Drug therapy Evidence level Effect Link (Pubmed)
LAML PML ATRA + arsenic trioxide FDA Approved(level 1) Sensitive 15103387
LAML RARA ATRA + arsenic trioxide FDA Approved(level 1) Sensitive 15103387
 Acute myeloid leukemia, NOS (AML NOS).
more info
5		 inv(16)(p13q22)

Drug Therapy

Cancer Type: LAML
Cancer descriptoin: Acute Myeloid Leukemia
Medical Subject Headings (MeSH): D015470
Diseases Database: 203
Cancer target Gene target Drug therapy Evidence level Effect Link (Pubmed)
LAML PML ATRA + arsenic trioxide FDA Approved(level 1) Sensitive 15103387
LAML RARA ATRA + arsenic trioxide FDA Approved(level 1) Sensitive 15103387
 Acute myeloid leukemia, NOS (AML NOS).
more info
6		 ins(17;15)(q21;q22q22)

Drug Therapy

Cancer Type: LAML
Cancer descriptoin: Acute Myeloid Leukemia
Medical Subject Headings (MeSH): D015470
Diseases Database: 203
Cancer target Gene target Drug therapy Evidence level Effect Link (Pubmed)
LAML PML ATRA + arsenic trioxide FDA Approved(level 1) Sensitive 15103387
LAML RARA ATRA + arsenic trioxide FDA Approved(level 1) Sensitive 15103387
 Acute promyelocytic leukemia (FAB type M3) (APML/APL/AML M3).
more info
7		 t(15;17)(q24;q21)

Drug Therapy

Cancer Type: LAML
Cancer descriptoin: Acute Myeloid Leukemia
Medical Subject Headings (MeSH): D015470
Diseases Database: 203
Cancer target Gene target Drug therapy Evidence level Effect Link (Pubmed)
LAML PML ATRA + arsenic trioxide FDA Approved(level 1) Sensitive 15103387
LAML RARA ATRA + arsenic trioxide FDA Approved(level 1) Sensitive 15103387
 Acute promyelocytic leukemia (FAB type M3) (APML/APL/AML M3).
Acute non lymphocytic leukemias (t-ANLL).
Atypical leukemia M3 ANLL (M3 ANLL).
more info
8		 ins(15;17)(q22;q21q21)

Drug Therapy

Cancer Type: LAML
Cancer descriptoin: Acute Myeloid Leukemia
Medical Subject Headings (MeSH): D015470
Diseases Database: 203
Cancer target Gene target Drug therapy Evidence level Effect Link (Pubmed)
LAML PML ATRA + arsenic trioxide FDA Approved(level 1) Sensitive 15103387
LAML RARA ATRA + arsenic trioxide FDA Approved(level 1) Sensitive 15103387
 Acute promyelocytic leukemia (FAB type M3) (APML/APL/AML M3).
more info
9		 t(15;17)(q21;q21)

Drug Therapy

Cancer Type: LAML
Cancer descriptoin: Acute Myeloid Leukemia
Medical Subject Headings (MeSH): D015470
Diseases Database: 203
Cancer target Gene target Drug therapy Evidence level Effect Link (Pubmed)
LAML PML ATRA + arsenic trioxide FDA Approved(level 1) Sensitive 15103387
LAML RARA ATRA + arsenic trioxide FDA Approved(level 1) Sensitive 15103387
 Acute promyelocytic leukemia (FAB type M3) (APML/APL/AML M3).
more info
10		 t(15;17)(q22;q21)
ALL

Drug Therapy

Cancer Type: ALL
Cancer descriptoin: Acute Lymphocytic Leukemia
Medical Subject Headings (MeSH): D054198
Diseases Database: 195
CML

Drug Therapy

Cancer Type: CML
Cancer descriptoin: Chronic Myelogenous Leukemia
Medical Subject Headings (MeSH): D015464
Diseases Database: 2659

Drug Therapy

Cancer Type: LAML
Cancer descriptoin: Acute Myeloid Leukemia
Medical Subject Headings (MeSH): D015470
Diseases Database: 203
Cancer target Gene target Drug therapy Evidence level Effect Link (Pubmed)
LAML PML ATRA + arsenic trioxide FDA Approved(level 1) Sensitive 15103387
LAML RARA ATRA + arsenic trioxide FDA Approved(level 1) Sensitive 15103387
More Descriptions

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